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Thromb Haemost 1972; 27(03): 554-558
DOI: 10.1055/s-0038-1649395
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

Intravenous Infusion of a Standardised Coagulation Active Phospholipid Complex in Uremic Coagulation Deficiency

Return to Normal of Thrombin Generation and Prothrombin Consumption
K.l Schimpf
1   Medical Department (Ludolf -Krehl-Klinik), University of Heidelberg, Germany, and the Department of Documentation, Information, and Statistics, German Cancer Research Center (Deutsches Krebsforschungszentrum) Heidelberg
,
H.-W Hanf-Hoppe
1   Medical Department (Ludolf -Krehl-Klinik), University of Heidelberg, Germany, and the Department of Documentation, Information, and Statistics, German Cancer Research Center (Deutsches Krebsforschungszentrum) Heidelberg
,
H Immich
1   Medical Department (Ludolf -Krehl-Klinik), University of Heidelberg, Germany, and the Department of Documentation, Information, and Statistics, German Cancer Research Center (Deutsches Krebsforschungszentrum) Heidelberg
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Publication History

Publication Date:
29 June 2018 (online)

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Summary

Infusion for 90 min of 10 ml brain lipid extract brought thrombin generation and prothrombin consumption levels in uremic patients to normal for 3 h. After quick injection of the same doses (within 3 min) the effect lasted less than l1/2h. Control subjects produced hypercoagulability with the same treatment. The results of these clinical experiments, obtained with 12 subjects, were shown by analysis of variance to be statistically significant.

 

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