Activation of Hageman Factor by Cardiac Arrest

Summary

The induction of cardiac arrest in rabbits for a period of 3min, followed by reestablishment for the circulation, resulted in a 27 % decrease in circulating Hageman factor. The maximum depletion occurred within 30 to 60 min and normal levels were restored by 4 h. Anti-contact product activity remained unchanged. Circulating platelets dropped by 17 % and small arterial thrombi were found predominantly in the lungs. It is concluded that cardiac arrest followed by re-circulation of the blood causes activation of Hageman factor. The proximate mechanism of this activation in experimental generalized anoxemia remains to be determined. Administration of a potent glucocorticoid prior to cardiac arrest markedly inhibited activation of the clotting mechanism.

^*) Present adress: Institut de Cardiologie de Montreal, 5000 Est, Rue Belanger, Montreal 410, Quebec, Canada.

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