The Effect of Alpha- and Beta-Receptor Blocking Agents on Collagen-Induced Platelet Release Reaction (A Comparison with ADP-Induced Release)

P Kubisz; J Suranova

doi:10.1055/s-0038-1649367

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1972; 27(02): 278-291
DOI: 10.1055/s-0038-1649367

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

The Effect of Alpha- and Beta-Receptor Blocking Agents on Collagen-Induced Platelet Release Reaction (A Comparison with ADP-Induced Release)

P Kubisz

¹Hemostasis Laboratory, Departmental Hospital, Čadca, Czechoslovakia

,

J Suranova

¹Hemostasis Laboratory, Departmental Hospital, Čadca, Czechoslovakia

› Author Affiliations

Abstract

Summary

The mechanism of the platelet release reaction, induced by collagen, is in certain respects different from that of ADP. Besides other facts, the PF 4 release and the availability of PF 3 and APh are not influenced by the concentrations of alpha or beta-receptor blocking agents which clearly interfere with the ADP-induced release.

The possible role of thrombosthenin (or its alpha-receptors in the participation of the release reaction is discussed.

Full Text

References

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