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Thromb Haemost 1972; 27(02): 272-277
DOI: 10.1055/s-0038-1649366
Originalarbeiten — Original Articles — Travaux Originaux
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Glutaraldehyde Fixation of Human Blood Platelets

J. J Sixma
*   Division of Haemostasis and Thrombosis, State University, Utrecht, The Netherlands
,
W. H Linssen
**   Department of Internal Medicine and Center for Medical Electron Microscopy, State University, Utrecht, The Netherlands
,
H. J Geuze
**   Department of Internal Medicine and Center for Medical Electron Microscopy, State University, Utrecht, The Netherlands
› Author Affiliations
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Publication History

Publication Date:
29 June 2018 (online)

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Summary

Hypertonic glutaraldehyde solutions produce dilatation of the surface connected system and shrinking of the cytoplasma. Hypertonic solutions produce swelling of the platelets. Good results are obtained with 1% glutaraldehyde M 0.07 M phosphate buffer (275 mosmol) 4 parts to 1 part platelet rich plasma. High glutaraldehyde concentrations do not affect the platelet ultrastructure.

 

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