A Simple and Practical Method for Isolation of an Early Plasmin Degradation Product of Human Fibrinogen

Summary

One of the earliest plasmin degradation products of human fibrinogen, so-called fragment A, was isolated by a simple method.

This peptide has a molecular weight of approximately 22,500, migrating electrophoretically at beta-area, and its amino acid composition shows a very high content of glycine, serine, threonine and proline, and a markedly low content of hydrophobic amino acids. This fragment does not react against anti-fibrinogen; however, the anti-serum of this fragment reacts strongly with fibrinogen.

• References

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