Thromb Haemost 1977; 37(03): 464-470
DOI: 10.1055/s-0038-1649256
Original Article
Schattauer GmbH

A Simple and Practical Method for Isolation of an Early Plasmin Degradation Product of Human Fibrinogen

Kimiteru Takagi
1   Department of Clinical Pathology, Jichi Medical School, 3311-1 Yakushiji, Minamikawachimachi, Kawachigun, Tochigi-Ken, Japan
,
Tadashi Kawai
1   Department of Clinical Pathology, Jichi Medical School, 3311-1 Yakushiji, Minamikawachimachi, Kawachigun, Tochigi-Ken, Japan
› Author Affiliations
Further Information

Publication History

Received 10 August 1976

Accepted 10 January 1977

Publication Date:
03 July 2018 (online)

Summary

One of the earliest plasmin degradation products of human fibrinogen, so-called fragment A, was isolated by a simple method.

This peptide has a molecular weight of approximately 22,500, migrating electrophoretically at beta-area, and its amino acid composition shows a very high content of glycine, serine, threonine and proline, and a markedly low content of hydrophobic amino acids. This fragment does not react against anti-fibrinogen; however, the anti-serum of this fragment reacts strongly with fibrinogen.

 
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