Marathon Run II: Effects on Platelet Aggregation

Summary

Platelet count and aggregation were assessed in 9 Finnish amateur runners aged 34 to 48, and one 65-year old taking part in a non-competitive marathon race (42.2 km).

After the run the mean value of platelet count showed a very significant rise (p <0.001). The platelets were markedly more sensitive to both ADP and collagen-induced aggregation. A highly significant increase (p <0.001) was noted for both the intensity and velocity of platelet aggregation.

The finding of platelet hyperaggregability after prolonged strenuous exercise even in trained subjects is discussed. It is concluded that a thorough medical examination of the haemostatic balance is recommended before a marathon race.

• References

• 1 Biggs R, Macfarlane R. G, Pilling J. Observations of fibrinolysis. Experimental activity produced by exercise or adrenaline. Lancet 1947; I: 402
• 2 Ferguson E. W, Guest M. M. Exercise, physical conditioning, blood coagulation and fibrinolysis. Thrombosis et Diathesis Haemorrhagica (Stuttg.) 1974; 31: 63
• 3 Finkel A, Cumming G. R. Effects of exercise in the cold on blood clotting and platelets. Journal of Applied Physiology 1965; 20: 423
• 4 Isaacs R, Gordon B. 25 The effect of exercise on the distribution of corpuscles in the blood. American Journal of Physiology 1924; 71: 106
• 5 Ikkala E, Myllyla G, Sarajas H. S. S. Platelet adhesiveness and ADP-induced platelet aggregation in exercise. Annales Medicinae Experimentalis Fenniae 1966; 44: 88
• 6 Mandalaki T, Dessypris A, Louizou C, Bossinakou I, Panayotopoulou C, Antonopoulou A. Marathon Run I: Effects on Blood Coagulation and Fibrinolysis. Thrombos. Haemostas. (Stuttgart) 1977; 37: 444
• 7 Poller L, Priest C. M, Thomson J. M. Platelet aggregation and strenuous exercise. Journal of Physiology 1971; 213: 525
• 8 Sarajas H. S. S, Konttinen A, Frick M. H. Haemostatic changes associated with exercise. Nature 1961; 192: 721
• 9 Sarajas H. S. S. Reaction Patterns of Blood Platelets in Exercise. In: V. Manninen, P. I. Halo-nen (Eds.) Physical Activity and Coronary Heart Disease. Third Paavo Nurmi Symposium Helsinki, Advances in Cardiology 18 S. Karger, Basel 1976: 176
• 10 Wachholder K, Parchwitz E, Egli H, und Kesseler K. Der Einfluß Körperlicher Arbeit auf die Zahl der Thrombocyten und auf deren Haftneigung. Acta Haematologica 1957; 18: 59