Thromb Haemost 1977; 37(03): 423-428
DOI: 10.1055/s-0038-1649250
Original Article
Schattauer GmbH

Cigarette-Smoking Effect on Platelet Function

G Grignani
1   Istituto di Clinica Medica Generale e Terapia Medica Iº “Adolfo Ferrata” (Direttore: Prof. E. Storti), Università degli Studi di Pavia, Italy
,
G Gamba
1   Istituto di Clinica Medica Generale e Terapia Medica Iº “Adolfo Ferrata” (Direttore: Prof. E. Storti), Università degli Studi di Pavia, Italy
,
E Ascari
1   Istituto di Clinica Medica Generale e Terapia Medica Iº “Adolfo Ferrata” (Direttore: Prof. E. Storti), Università degli Studi di Pavia, Italy
› Author Affiliations
Further Information

Publication History

Received 02 August 1976

Accepted 04 March 1977

Publication Date:
03 July 2018 (online)

Summary

The immediate effect of cigarette-smoking on ADP-induced platelet aggregation and on platelet adhesiveness was investigated in 12 normal subjects aged 20 to 40, in 10 normal subjects aged 43 to 72 and in 10 patients with cerebrovascular disease aged 45 to 75.

All the subjects were heavy smokers (more than 20 cigarettes a day).

After smoking 2 cigarettes a significant increase in ADP aggregation and platelet adhesiveness was found in the group of young heavy smokers, while in the old subjects with or without cerebrovascular disease the increase in platelet activity was never significant.

These data were discussed and some hypotheses for this higher reactivity of platelets from young people were suggested.

 
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