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Thromb Haemost 1977; 37(02): 192-200
DOI: 10.1055/s-0038-1649219
Original Article
Schattauer GmbH

Soluble Fibrin Complexes in Early Fibrin Digests*

Luddo B. Nanninga
1   Department of Physiology and Biophysics, University of Texas Medical Branch Galveston, Texas 77550, USA
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Further Information

Publication History

Received 10 November 1975

Accepted 30 October 1976

Publication Date:
03 July 2018 (online)

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Summary

Early fibrin digests were analyzed in the ultracentrifuge and were found to contain compounds with molecular weights up to 3 x 106; these compounds are considered to be soluble fibrin complexes. Their similarity with intermediate polymers in inhibited clotting systems has been stressed. Their viscosity at low shear rates is extremely high; therefore, a rapid method to establish their presence in plasma would be the measurement of plasma and serum viscosity at low shear rates. Moreover, they shorten the clotting time (thrombin time) of fibrinogen considerably.

* * Presented in part at F.A.S.E.B. conference in 1976.


 

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