Thromb Haemost 1977; 37(01): 136-143
DOI: 10.1055/s-0038-1649211
Original Article
Schattauer GmbH

Immunoelectrophoretic Studies on the Kinetics of Plasmic Degradation of Human Fibrinogen[*]

Roberto Braude
1  Departamento de Docencia e Investigación (Head: Dr. Raúl Altman) Hospital U.A.M.I.-Rivadavia-Peralta Ramos
,
Raúl Altman
1  Departamento de Docencia e Investigación (Head: Dr. Raúl Altman) Hospital U.A.M.I.-Rivadavia-Peralta Ramos
,
Jorge Rouvier
1  Departamento de Docencia e Investigación (Head: Dr. Raúl Altman) Hospital U.A.M.I.-Rivadavia-Peralta Ramos
,
Nélida Aguilar
1  Departamento de Docencia e Investigación (Head: Dr. Raúl Altman) Hospital U.A.M.I.-Rivadavia-Peralta Ramos
› Institutsangaben
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Publikationsverlauf

Received 06. November 1975

Accepted 20. Juli 1976

Publikationsdatum:
03. Juli 2018 (online)

Summary

In vitro degradation of fibrinogen results in the appearance of an early fragment, different in its electrophoretic mobility to that of fragments X, Y, D and E.

It reacts with antifibrinogen antiserum, does not react with anti-D antiserum and it is anti-genically related to fragment E.

Compared with terminal fragment E, it migrates more slowly towards the anode, it appears earlier and in a greater concentration at the beginning, decreasing and disappearing during degradation.

The antigen antibody crossed electrophoresis was used in these experiments, but to distinguish the fragments from already known X, Y or even fibrinogen, the applying of an intermediate gel with anti D was of great value.

* Presented in part at the Vth Congress of the International Society on Thrombosis and Haemostasis, Paris 1975.