Thromb Haemost 1977; 37(01): 081-085
DOI: 10.1055/s-0038-1649204
Original Article
Schattauer GmbH

Kinetic Aspects of the Interaction of Blood Clotting Enzymes

VII. The Relation between Clotting Time and Prothrombin Concentration
H. C Hemker
1   Department of Biochemistry, Biomedical Centre, State University Limburg, Maastricht, The Netherlands
,
C Vermeer
1   Department of Biochemistry, Biomedical Centre, State University Limburg, Maastricht, The Netherlands
,
J Govers-Riemslag
1   Department of Biochemistry, Biomedical Centre, State University Limburg, Maastricht, The Netherlands
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received 12. Februar 1976

Accepted 20. August 1976

Publikationsdatum:
03. Juli 2018 (online)

Summary

The relation between clotting time and the inverse of prothrombin concentration is shown to be rectilinear.

 
  • References

  • 1 Hemker H.G, Hemker P.W, Loeliger E.A. Kinetic aspects of the interaction of blood clotting enzymes. I. Derivation of basic formulas. Thrombosis et Diathesis Haemorrhagica 1965; 13: 155
  • 2 Hemker H.C, Muller A.D. Kinetic aspects of the interaction of blood clotting enzymes. V. One-stage estimations in the extrinsic coagulation system. Thrombosis et Diathesis Haemorrhagica 1968; 19: 368
  • 3 Hemker H.C, Swart A.C.W, Alink A.M.J. Artifícal reagents for factor VII and X, a computer program for obtaining reference tables for one-stage determinations in the extrinsic system. Thrombosis et Diathesis Haemorrhagica 1972; 27: 205
  • 4 Owen W.G, Esmon G.T, Jackson W.M. The conversion of prothrombin to thrombin. I. Characterization of the reaction products formed during the activation of bovine prothrombin. Journal of Biological Chemistry 1974; 249: 594
  • 5 Vermeer C, Soute B.A.M, Hemker H.C. A new method for the preparation of artificial factor II reagents from normal human and bovine plasma. Submitted for publication 1976