Summary
Labeling of platelets in vivo by 75Se – Selenomethionine (75Se-M) was performed in nine cases of hepatic cirrhosis and thrombocytopenia for evaluation
of the kinetics of platelet maturation. Folic acid and vitamin B12 deficiency was excluded by pretreatment of the patients with these agents. The platelet
maturation time – time between the injection of the isotope and maximum radioactivity
of separated blood platelets – was shortened to 7.7±1.1 days (mean±SD) compared to
the normal of 9.1±1.4 days. For explanation a disturbance of megakaryocyte maturation
and/or platelet release from the bone marrow is suggested.
