Thromb Haemost 1977; 37(01): 047-052
DOI: 10.1055/s-0038-1649200
Original Article
Schattauer GmbH

In Vivo Labeling of Platelets with 75Se – Selenomethionine in Patients with Hepatic Cirrhosis and Thrombocytopenia.

Manfred Mayer
1  First Department of Internal Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, BRD
,
Ilse Herrmann
1  First Department of Internal Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, BRD
,
Uwe Kempgens
1  First Department of Internal Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, BRD
,
Wolfgang Queisser
1  First Department of Internal Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, BRD
› Author Affiliations
Further Information

Publication History

Received 06 June 1976

Accepted 13 August 1976

Publication Date:
03 July 2018 (online)

Summary

Labeling of platelets in vivo by 75Se – Selenomethionine (75Se-M) was performed in nine cases of hepatic cirrhosis and thrombocytopenia for evaluation of the kinetics of platelet maturation. Folic acid and vitamin B12 deficiency was excluded by pretreatment of the patients with these agents. The platelet maturation time – time between the injection of the isotope and maximum radioactivity of separated blood platelets – was shortened to 7.7±1.1 days (mean±SD) compared to the normal of 9.1±1.4 days. For explanation a disturbance of megakaryocyte maturation and/or platelet release from the bone marrow is suggested.