Studies on the Characterization of Factor VIII and a Co-factor VIII

M. M. P Paulssen; H. L. M. A Vandenbussche-Scheffers; P. B Spaan; T de Jong; M. C Planje

doi:10.1055/s-0038-1649167

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1974; 31(02): 328-338
DOI: 10.1055/s-0038-1649167

Original Article

Schattauer GmbH

Studies on the Characterization of Factor VIII and a Co-factor VIII

M. M. P Paulssen

¹Department of Clinical biochemistry, St. Clara Hospital, Rotterdam, Netherlands

²Central Animal Laboratory of the University of Nijmegen, Netherlands (Head: Dr. M. J. Dobbelaar)

,

H. L. M. A Vandenbussche-Scheffers

¹Department of Clinical biochemistry, St. Clara Hospital, Rotterdam, Netherlands

²Central Animal Laboratory of the University of Nijmegen, Netherlands (Head: Dr. M. J. Dobbelaar)

,

P. B Spaan

¹Department of Clinical biochemistry, St. Clara Hospital, Rotterdam, Netherlands

²Central Animal Laboratory of the University of Nijmegen, Netherlands (Head: Dr. M. J. Dobbelaar)

,

T de Jong

¹Department of Clinical biochemistry, St. Clara Hospital, Rotterdam, Netherlands

²Central Animal Laboratory of the University of Nijmegen, Netherlands (Head: Dr. M. J. Dobbelaar)

,

M. C Planje

¹Department of Clinical biochemistry, St. Clara Hospital, Rotterdam, Netherlands

²Central Animal Laboratory of the University of Nijmegen, Netherlands (Head: Dr. M. J. Dobbelaar)

› Institutsangaben

Abstract

Summary

Factor VIII occurs in the body in two different forms. In lymph factor VIII is bound to chylomicra. In plasma, factor VIII is bound to a protein.

After delipidation of chylomicra we obtained a glycoprotein with a high polysaccharide content and a molecular weight of approx. 160,000.

In plasma, factor VIII is attached to a protein which is present in normal concentrations in plasma of patients with haemophilia A and in serum (co-factor VIII).

This factor is deficient in both the plasma and the serum of patients with von Willebrand’s disease.

The binding between factor VIII and co-factor VIII is reversible.

Some properties of these two factors are described.

Volltext

Referenzen

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