Thromb Haemost 1974; 31(01): 103-118
DOI: 10.1055/s-0038-1649149
Original Article
Schattauer GmbH

The Relationship between Blood Coagulation and Thrombosis and Atherosclerosis in Man, Monkeys and Carnivores

Christine M Hawkey
1   Nuffield Institute of Comparative Medicine, Zoological Society of London, Regent’s Park, London, N.W.1.
› Author Affiliations
Further Information

Publication History

Received 10 August 1973

Accepted 12 October 1973

Publication Date:
29 June 2018 (online)

Summary

A comparative survey of the blood coagulation mechanism has been carried out in man, non-human primates and carnivores. In man, the average rate of conversion of fibrinogen to fibrin by thrombin is slightly faster and the ability of plasma to neutralise thrombin is less than in the animal species. Otherwise, in general, the activity of the clotting mechanism in monkeys and carnivores is equal to or greater than that of man. These results do not explain the increased susceptibility to spontaneous cardiovascular disease seen in the human species.

 
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