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Thromb Haemost 1973; 30(02): 381-392
DOI: 10.1055/s-0038-1649088
DOI: 10.1055/s-0038-1649088
Original Article
Studies on Activator Formation in Human Plasma with Streptokinase
I. Experimental StudiesFurther Information
Publication History
Received for publication
08 December 1972
Accepted for publication
16 May 1973
Publication Date:
24 July 2018 (online)
Summary
The plasminogen-streptokinase complex called “activator” was present in diluted plasma in the form of a largely dissociated mixture. More than ⅞ of the streptokinase and plasminogen molecules were available for further activator formation.
The activator is probably a dissociated complex of the formula
Streptokinase + Plasminogen ⇄ Activator.
The fact that an increase in activator concentration by x times is obtained by multiplying either the streptokinase content by the factor y or the plasminogen concentration by the same factor y would point to a kinetic effect along the lines of the mass action law.
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