Generalized Shwartzman Reaction Induced by Liquoid in the Rat

Summary

In an autoradiographic study the number of DNA-synthesizing aortic endothelial cells was compared 48 hours after an intravenous injection of the acidic polymer Liquoid or saline in rats. Doses of 1.5-2 mg per 100 g body weight produced a 14-fold increase in DNA-synthesizing endothelial cells and the generalized Shwartzman reaction. These results show that Liquoid causes severe endothelial injury.

^* Present adress: Medical Department A, Rikshospitalet, Oslo 1, Norway

• References

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