Download PDF
Thromb Haemost 1972; 28(02): 182-193
DOI: 10.1055/s-0038-1649054
Original Article
Schattauer GmbH

Cold Promoted Activation of Factor VII

III. Relation to the Kallikrein System
H Gjønniess
1   Institute for Thrombosis Research, University of Oslo, Rikshospitalet, (Chief: H. Stormorken) Oslo, Norway
› Author Affiliations
Further Information

Publication History

Publication Date:
29 June 2018 (online)

    Permissions and Reprints

Summary

Several known activators of the plasma kallikrein system were tested for the ability to induce cold promoted activation of factor VII.

All the prekallikrein activators tested (EACA, trypsin, acetone, urokinase, kaolin, Liquoid, ellagic acid) revealed generation of factor VII activator activity (CPA). Simultaneously the plasma kallikrein system was activated. A good correlation was demonstrated between the factor VII activation and the kallikrein activity.

Glandular kallikrein, bradykinin, or kallidin revealed no effect on the coagulation system. Thus, the correlation between the factor VII activation and the kallikrein system seemed to be restricted to plasma kallikrein.

 

  • References

  • 1 Ablondi F. B, Hagan J. J, Philips M, and De Renzo E. C. 1959; Inhibition of plasmin, trypsin and the streptokinase-activated fibrinolytic system by E-amino-caproic acid. Archives of Biochemistry and Biophysics 82: 153.
    CrossrefPubMedGoogle Scholar
  • 2 Alkjaersig N, Fletcher A. P, and Sherry S. 1959; E-aminocaproic acid; an inhibitor of plasminogen activation. Journal of Biological Chemistry 234: 832.
    PubMedGoogle Scholar
  • 3 Altman R, and Hemker H. C. 1967; Contact activation in the extrinsic blood clotting system. Thrombosis et Diathesis Haemorrhagica 18: 525.
    PubMedGoogle Scholar
  • 4 Armstrong D, Jepson J. B, Keele C. A, and Stewart J. W. 1955; Activation by glass of pharmacologically active agents in blood of various species. Journal of Physiology 129: 80P.
    PubMedGoogle Scholar
  • 5 Armstrong D, and Stewart J. W. 1960; Formation of plasma kinin in human plasma by E-amino caproic acid and certain related compounds. Journal of Physiology 154: 19 P.
    PubMedGoogle Scholar
  • 6 Armstrong D, Mills G. L, and Stewart J. W. 1967 Thermally induced effects on the kininforming system of native human plasma, 37°-0° C and 37°-50° C. International Symposium on Vasoactive Polypeptides: Bradykinin and related Kinins. M. Rocha e Silva & H. A. Rotschild, São Paulo.
    PubMedGoogle Scholar
  • 7 Back N, Guth P. S, and Munson A. E. 1963; On the relationship between plasmin and kinin. Annals of the New York Academy of Sciences 104: 53.
    PubMedGoogle Scholar
  • 8 Briseid K, Arntzen F. C, and Dyrttd O. K. 1968; Studies on the release of kinin by acetone in human plasma. Acta pharmacologica et toxicologica 26: 402.
    PubMedGoogle Scholar
  • 9 Briseid K, Dyrud O. K, and Rinvik S. F. 1967; In vitro estimation of the rate of release of kinin in human plasma. Acta pharmacologica et toxicologica 25: 201.
    PubMedGoogle Scholar
  • 10 Bijluk K, Czokalo M, and Malofiejew M. 1970; Contact and plasmin kinin-forming systems in the blood. Thrombosis et Diathesis Haemorrhagica 24: 548.
    PubMedGoogle Scholar
  • 11 Colman R. W, Mason J. H, and Sherry S. 1969; The kallikreinogen-kallikrein enzyme system of human plasma. Annals of Internal Medicine 71: 763.
    CrossrefPubMedGoogle Scholar
  • 12 Eisen V. 1963; Kinin formation and fibrinolysis in human plasma. Journal of Physiology 166: 514.
    CrossrefPubMedGoogle Scholar
  • 13 Evensen S. A, and Jeremio M. 1968; Intravascular coagulation with generalized Schwartzman reaction induced by Liquoid: Lack of protection by extreme thrombocytopenia. Thrombosis et Diathesis Haemorrhagica 19: 556.
    PubMedGoogle Scholar
  • 14 Gjønnæss H. 1972; a Cold promoted activation of factor VII. I. Evidence for the existence of an activator. Thrombosis et Diathesis Haemorrhagica 28: 155.
    PubMedGoogle Scholar
  • 15 Gjønnæss H. 1972; b Cold promoted activation of factor VII. II. Identification of the activator. Thrombosis et Diathesis Haemorrhagica 28: 169.
    PubMedGoogle Scholar
  • 16 Gjønnæss H. 1972; d Cold promoted activation of factor VII. IV: Relation to the coagulation system. Thrombosis et Diathesis Haemorrhagica 28: 194.
    PubMedGoogle Scholar
  • 17 Gjønnæss H. 1972 e Cold promoted activation of factor VII. V. Relation to the fibrinolytic system. Thrombosis et Diathesis Haemorrhagica, accepted for publication.
    PubMedGoogle Scholar
  • 18 Godal H. C, and Gjengedal G. 1971; Activation of coagulation by heparin-protamine complexes as demonstrated by Thrombotest. Scandinavian Journal of Haematology 8: 194.
    PubMedGoogle Scholar
  • 19 Godal H. C, and Theodor I. 1965; In vitro inhibition of streptokinase-induced proteolysis by trasylol and by epsilon amino caproic acid (EACA). Scandinavian Journal of Clinical and Laboratory Investigation Suppl. 84: 199.
    PubMedGoogle Scholar
  • 20 Habermann E. 1968; Zur Frage der Beziehung zwischen Kininsystem und allergischen Prozessen. Deutsche medizinische Wochenschrift 93: 40.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 21 Hamberg U, and Rocha e Silva M. 1957; Release of bradykinin as related to the esterase activity of trypsin and of the venom of Bothrops Jararaca. Experientia 13: 489.
    CrossrefPubMedGoogle Scholar
  • 22 Jahrreiss R, and Habermann E. 1971; On the endogenous mechanism of kinin release I. Naunyn-Schmiedeberg’s Archiv für Pharmakologie 269: 85.
    PubMedGoogle Scholar
  • 23 Johnston C. L, and Hjort P. F. 1964; Development of increased factor VII activity during the spontaneous coagulation of blood. Journal of Clinical Investigation 40: 743.
    PubMedGoogle Scholar
  • 24 Kaplan A. P, and Austen K. F. 1970; A pre-albumin activator of prekallikrein. Journal of Immunology 105: 802.
    PubMedGoogle Scholar
  • 25 Kraut H, Frey E. K, and Werle E. 1933; Über den Nachweis und das Vorkommen des Kallikreins im Blut. Hoppe-Seylers Zeitschrift für physiologische Chemie 222: 73.
    PubMedGoogle Scholar
  • 26 Landmann H, Markwardt F, and Perlewitz J. 1969; Die Beeinflussung der Wirkung des Trypsins auf die Blutgerinnung durch natürliche und synthetische Trypsin-und Thrombininhibitoren. Thrombosis et Diathesis Haemorrhagica 22: 552.
    PubMedGoogle Scholar
  • 27 Lewis G. P. 1958; Formation of plasma kinins by plasmin. Journal of Physiology 140: 285.
    CrossrefPubMedGoogle Scholar
  • 28 Margolis J. 1958; Activation of plasma by contact with glass : Evidence for a common reaction which releases plasma kinin and initiates coagulation. Journal of Physiology 144: 1.
    PubMedGoogle Scholar
  • 29 Margolis J, and Bishop E. A. 1962; Interrelations between different mechanisms of release of biologically active peptides from blood plasma. Nature 194: 749.
    CrossrefPubMedGoogle Scholar
  • 30 Müller-Berghaus G, and Lasch H. G. 1970; Consumption of Hageman factor activity in the generalized Schwartzman reaction induced by Liquoid. Thrombosis et Diathesis Haemorrhagica 23: 386.
    PubMedGoogle Scholar
  • 31 Nagasawa S, Takashi H, Koida M, Suzuki T, and Schoenmakers J. G. G. 1968; Partial purification of bovine plasma kallikreinogen, its activation by the Hageman factor. Biochemical and Biophysical Research Communications 32: 644.
    CrossrefPubMedGoogle Scholar
  • 32 Nilsson I. M, Sjoerdsma A, and Waldenstrom J. 1960; Antiflbrinolytic activity and metabolism of E-amino-caproic acid in man. Lancet 1: 1327.
    PubMedGoogle Scholar
  • 33 Owren P. A. 1959; Thrombotest. A new method for controlling anticoagulant therapy. Lancet 2: 754.
    PubMedGoogle Scholar
  • 34 Prydz H. 1965. Studies on proconvertin (F. VII). Universitetsforlaget; Oslo:
    Google Scholar
  • 35 Ratnoff O. D, and Crum J. D. 1964; Activation of Hageman factor by solutions of ellagic acid. Journal of Laboratory and Clinical Medicine 63: 359.
    PubMedGoogle Scholar
  • 36 Ratnoff O. D, and Miles A. A. 1964; The induction of permeability-increasing activity in human plasma by activated Hageman factor. British Journal of Experimental Pathology 45: 328.
    PubMedGoogle Scholar
  • 37 Ratnoff O. D, and Rosenblum J. M. 1958; Role of Hageman factor in the initiation of clotting by glass. American Journal of Medicine 25: 160.
    CrossrefPubMedGoogle Scholar
  • 38 Rinvik S. F, Dyrud O. K, and Briseid K. 1966; Determination of plasma kininogen, plasma kininase and erythrocyte kininase. Acta pharmacologica et toxicologica 24: 169.
    PubMedGoogle Scholar
  • 39 Rocha e Silva M, Reis M. L, and Ferreira S. H. 1967; Release of kinins from fresh plasma under varying experimental conditions. Biochemical Pharmacology 16: 1665.
    CrossrefPubMedGoogle Scholar
  • 40 Schrogie J. J, Solomon H. M, and Zieve P. D. 1967; Effect of oral contraceptives on vitamin K-dependent clotting activity. Clinical Pharmacology and Therapeutics 8: 670.
    PubMedGoogle Scholar
  • 41 Stormorken H. 1956; The effect of Trypsin on blood coagulation and the mechanism of its action. Journal of Laboratory and Clinical Medicine 48: 519.
    PubMedGoogle Scholar
  • 42 Vogt W. 1964; Kinin formation by plasmin, an indirect process mediated by activation of kallikrein. Journal of Physiology 170: 153.
    CrossrefPubMedGoogle Scholar
  • 43 Vogt W. 1965; Ein komplettes zweites kininbildendes System in menschlichem Plasma. Naunyn-Schmiedeberg’s Archiv für Pharmakologie und experimentelle Pathologie 251: 186.
    PubMedGoogle Scholar
  • 44 Waaler B. A. 1959. Contact activation in the intrinsic blood clotting system. Thesis. Oslo University Press; Oslo:
    Google Scholar
  • 45 Webster M. E. 1966; The kallikrein-kininogen-kinin-system. Arthritis and Rheumatism 9: 473.
    CrossrefPubMedGoogle Scholar
  • 46 Webster M. E. 1968; Human plasma kallikrein, its activation and pathological role. Federation Proceedings 27: 84.
    PubMedGoogle Scholar
  • 47 Webster M. E, and Pierce J. V. 1961; Action of the kallikreins on synthetic ester substrates. Proceedings of the Society for Experimental Biology and Medicine 107: 186.
    PubMedGoogle Scholar
  • 48 Webster M. E, and Pierce J. V. 1967 Studies on the enzymes involved in the activation of human plasma kallikrein. International Symposium on Vaso-active Polypeptides: Bradykinin and related Kinins. São Paulo.
    PubMedGoogle Scholar
  • 49 Werle E. 1960. Kallikrein, kallidin and related substances. Symposium: Polypeptides which affect smooth muscles and blood vessels. Schachter M. (ed.) Pergamon; London:
    Google Scholar
  • 50 Werle E, Forell M. M, and Maier L. 1955; Zur Kenntnis der blutdrucksenkenden Wirkung des Trypsins. Archiv für experimentelle Pathologie und Pharmakologie 225: 369.
    PubMedGoogle Scholar