Cold Promoted Activation of Factor VII

H Gjønnæss

doi:10.1055/s-0038-1649053

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1972; 28(02): 169-181
DOI: 10.1055/s-0038-1649053

Original Article

Schattauer GmbH

Cold Promoted Activation of Factor VII

II. Identification of the Activator

H Gjønnæss

¹Institute for Thrombosis Research, University of Oslo, Rikshospitalet, (Chief H. Stormorken), Oslo, Norway

› Author Affiliations

Abstract

Summary

The activating principle (CPA) of the factor VII activation seen in plasmas of women taking oral contraceptives after overnight incubation of the plasmas at 0° C was investigated. The reaction was dependent on low temperature, and factor XII was indispensable. Concomitant with the activation of factor VII a 10–30 fold increase in TAME esterolytic activity was observed together with a near 100 per cent drop in plasma kininogen concentration. The results indicated that the activation of factor VII is linked to activation of the kallikrein system, and that the activator may be plasma kallikrein.

Full Text

References

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