Influence of Factor VII on the Assay of Factor VIII by the One Stage Method Using Wettable Surface

Raúl Altman; Jorge Rouvier; Carlos Reussi; with the technical assistance of Silvia M. Taboada

doi:10.1055/s-0038-1649029

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1972; 28(03): 457-463
DOI: 10.1055/s-0038-1649029

Original Article

Schattauer GmbH

Influence of Factor VII on the Assay of Factor VIII by the One Stage Method Using Wettable Surface

Authors

Raúl Altman M. D.

¹Section on Hemostasis and Thrombosis, Department of Internal Medicine and Department of Docencia e Investigación, U.A.M. I. Rivadavia-Peralta Ramos, Buenos Aires, Argentina
Jorge Rouvier M. D.

¹Section on Hemostasis and Thrombosis, Department of Internal Medicine and Department of Docencia e Investigación, U.A.M. I. Rivadavia-Peralta Ramos, Buenos Aires, Argentina
Carlos Reussi M. D.

¹Section on Hemostasis and Thrombosis, Department of Internal Medicine and Department of Docencia e Investigación, U.A.M. I. Rivadavia-Peralta Ramos, Buenos Aires, Argentina

with the technical assistance of Silvia M. Taboada

Abstract

Summary

The influence of factor VII activated by Contact Product (i. e. the product of the reaction between factor XII and XI) on the factor VIII determination by the partial thromboplastin time with kaolin is described. There is an important decrease in clotting time when, with a constant amount of factor VIII, the concentration of factor VII is increased. This difference is unimportant from a practical point of view; but this does not distract from the possibility that the minute amount of thrombin generated by the XII-VII pathway may be of great practical interest, because it may be capable of activation factors V and VIII as well as influencing platelet metabolism and thus induce hemostasis, especially when the intrinsic pathway is blocked.

Full Text

References

References
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