Summary
Analysis of naturally occurring protein mutations yields valuable insights into functionally
important sequences. Characterizing mutations responsible for protein C deficiency
at the molecular level has been the subject of intensive investigation. In a previous
study, a three-dimensional model of the serine protease domain of protein C was used
to analyze the set of protease domain mutations previously available. The mutations
were largely found to fall into a limited number of categories. A recently updated
protein C mutation data base has provided a number of new mutations which have been
analyzed for structural predictions.
