The Role of Myosin Phosphorylation in Regulating Actin-Myosin Interaction in Human Blood Platelets^[*]

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^* Invited Symposium V “Platelets: Intravascular Control Mechanisms” presented to VIth International Congress on Thrombosis and Haemostasis, philadelphia, U. S. A. June 1977.

• References

• 1 Adelstein RS, Chacko S, Barylko B, Scordilis SP, Conti MA. 1976. The role of myosin phosphorylation in the regulation of platelet and smooth muscle contractile proteins. In: Perry SV, Margreth A, Adelstein RS. (eds.) Contractile systems in non-muscle tissues; North Holland, Amsterdam: pp 153-163
• 2 Adelstein RS, Chacko S, Scordilis SP, Barylko B, Conti MA, Trotter JA. 1977. a The role of Ca²⁺and myosin phosphorylation in regulating actomyosin in smooth muscle and nonmuscle cells. In Wasserman RH, Corradino RA, Carafoli E, Kretsinger RH, Maclennan DH, Siegel FL. (eds.) Calcium-binding proteins and calcium function; North Holland, Amsterdam: pp 251-261
• 3 Adelstein RS, Conti MA, Scordilis SP, Chacko S, Barylko B, Trotter JA. 1977. b Myosin phosphorylation as a regulatory mechanism. in: Casteels R, Godfraind T, Ruegg JC. (eds.) Excitation-contraction coupling in smooth muscle; North Holland, Amsterdam: (In the press)
• 4 Adelstein RS, Conti MA. 1975; Phosphorylation of platelet myosin increases actin-activated myosin ATPase activity. Nature, London 256: 597
• 5 Adelstein RS, Conti MA, Daniel JL, Erson Jr W. 1975. The interaction of platelet actin, myosin and myosin light chain kinase. Biochemistry and Pharmacology of Platelets CIBA Foundation Symposium 35 (New series). Elsevier; Amsterdam: pp 101-119
• 6 Adelstein RS, Conti MA, Erson Jr W. 1973; Phosphorylation of human platelet myosin. Proceedings of the National Academy of Science USA 70: 3115
• 7 Barylko B, Conti MA, Adelstein RS. 1977; Properties of platelet myosin phosphatase. Biophysical Journal 17: 270 a
• 8 Chacko S, Conti MA, Adelstein RS. 1977; Effect of phosphorylation of smooth muscle myosin on actin activation and Ca²⁺regulation. Proceedings of the National Academy of Science USA 74: 129
• 9 Daniel JL, Adelstein RS. 1976; Isolation and properties of platelet myosin light chain kinase. Biochemistry 15: 2370
• 10 Daniel JL, Holmsen H, Adelstein RS. 1977 Thrombinstimulated myosin phosphorylation in intact platelets and its possible involvement in secretion. Thrombosis and Haemostasis. (in the press)
• 11 Gorecka A, Aksoy MO, Hartshorne DJ. 1976; The effect of phosphorylation of gizzard myosin on actin-activation. Biochemical Biophysical Research Communication 71: 325
• 12 Haslam RJ, Lynham JA. 1977; Relationship between phosphorylation of blood platelet proteins and secretion of platelet granule constituents. I. Effects of different aggregating agents. Biochemical Biophysical Research Communications 71: 325
• 13 Lyons RM, Stanford N, Majerus PW. 1975; Thrombin-induced protein phosphorylation in human platelets. Journal of Clinical Investigations 56: 924
• 14 Morgan M, Perry SV, Ottaway J. 1976; Myosin light chain phosphatase. Biochemical Journal 157: 687
• 15 Scordilis SP, Erson JL, Pollack R, Adelstein RS. 1977; Characterization of the myosin-phosphorylating system in normal murine astrocytes and derivative SV40 wild-type and A- mutant transformants. Journal of Cell Biology 74: 940
• 16 Scordilis SP, Adelstein RS. 1977; Myoblast myosin phosphorylation is a prerequisite for actin-activation. Nature London 268: 558
• 17 Small JV, Sobieszek A. 1977; Ca-regulation of mammalian smooth muscle actomyosin via a kinase-phosphatase-dependent phosphorylation and dephosphorylation of the 20,000-Mr light chain of myosin. European Journal of Biochemistry 76: 521
• 18 Sobieszek A, Small JV. 1977; Regulation of the actin-myosin interaction in vertebrate smooth muscle: Activation via a myosin light-chain kinase and the effect of tropomyosin. Journal of Molecular Biology 112: 559