J Pediatr Infect Dis 2019; 14(03): 144-148
DOI: 10.1055/s-0038-1648245
Rapid Communication
Georg Thieme Verlag KG Stuttgart · New York

Impact of Matrix-Assisted Laser Desorption/Ionization Time-of-Flight for the Identification of Gram-Positive Bloodstream Pathogens without Antimicrobial Stewardship Intervention in Hospitalized Children

Lisa Herrera
1  The University of New Mexico School of Medicine, Albuquerque, New Mexico, United States
Karissa Culbreath
2  Tricore Reference Laboratories, Albuquerque, New Mexico, United States
Walter Dehority
3  Division of Infectious Diseases, Department of Pediatrics, The University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States
› Author Affiliations
Funding This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Further Information

Publication History

16 January 2018

26 March 2018

Publication Date:
03 May 2018 (eFirst)


We performed a 2-year retrospective cohort study of inpatient children with growth of gram-positive bacteria from blood cultures identified with and without the use of matrix-assisted laser-desorption/ionization time-of-flight (MALDI-TOF) in the absence of an antimicrobial stewardship program. Use of MALDI-TOF reduced the time to organism identification by 15.7 hours (p < 0.0001). However, no differences in length of stay, time to optimization of antimicrobial therapy, or time to discontinuation of antibiotics for growth of contaminants were documented, suggesting that such potential patient-oriented benefits of MALDI-TOF may only be evident in the presence of a concurrent antimicrobial stewardship program.