Summary
A synthetic hirudinsgs55-65 C-terminal fragment analog was evaluated for anticoagulant activity and in models
of experimental thrombosis in mice and rats. Intravenous injection caused doserelated
inhibition of thrombin and anticoagulation in rat blood samples, protection from thromboembolism
in mice and inhibition of stasis-induced venous thrombosis in rats. Antithrombotic
effectiveness corresponded with anticoagulant activity. Anephric animals exhibited
longer duration of activity than normal animals suggesting the kidney as a major route
of elimination.
