Thromb Haemost 1973; 29(03): 701-711
DOI: 10.1055/s-0038-1648113
Original Article
Schattauer GmbH

Lipid Infusions in Man

Blood Platelet Uptake of Lipid and Effects on Platelet Functions
K. A Grøttum
1   Section of Haematology (Chief, Professor P. F. Hjort), Medical Department A (Chief, Professor E. Gjone): Institute for Thrombosis Research (Chief, Professor H. Stormorken), Rikshospitalet, Oslo, Norway
,
A Nordøy
1   Section of Haematology (Chief, Professor P. F. Hjort), Medical Department A (Chief, Professor E. Gjone): Institute for Thrombosis Research (Chief, Professor H. Stormorken), Rikshospitalet, Oslo, Norway
,
A Hellem
1   Section of Haematology (Chief, Professor P. F. Hjort), Medical Department A (Chief, Professor E. Gjone): Institute for Thrombosis Research (Chief, Professor H. Stormorken), Rikshospitalet, Oslo, Norway
› Author Affiliations
Further Information

Publication History

Publication Date:
24 July 2018 (online)

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Summary

The soybean lipid emulsion Intralipid was infused during two hours in 13 volunteer individuals. Biochemically, lipid infusions increased the platelet content of triglycerides, but did not cause significant platelet aggregation, and the platelet counts and survival time were unchanged. However, the lipid infusions reduced platelet and erythrocyte electrophoric mobility, reduced the availability of platelet factor 3 by ADP or kaolin and reduced platelet adhesiveness. A coating of parts of the platelet surface by lipid particles or some other changes in the platelet membrane could explain the effects on platelet electrophoretic mobility, platelet factor 3, and adhesiveness.