Download PDF
Thromb Haemost 1973; 29(03): 610-618
DOI: 10.1055/s-0038-1648103
Original Article
Schattauer GmbH

Decreased Fibrinolysis in Behçet’s Disease

Tova Chajek
1   Departments of Hematology and Medicine B, Hadassah University Hospital, Jerusalem, Israel
,
Eta Aronowski
1   Departments of Hematology and Medicine B, Hadassah University Hospital, Jerusalem, Israel
,
G Izak
1   Departments of Hematology and Medicine B, Hadassah University Hospital, Jerusalem, Israel
› Author Affiliations
Further Information

Publication History

Publication Date:
30 June 2018 (online)

Also available at
    Permissions and Reprints

Summary

The coagulation and fibrinolytic systems have been investigated in nine patients suffering from Behçet’s disease. Six of these had thrombophlebitis.

The results of these studies revealed markedly elevated fibrinogen concentration and increased factor VIII activity as well as a pronounced decrease in the spontaneous fibrinolytic activity. This latter finding may have resulted from the presence of a potent antiplasmin activity and that of an inhibitor of the plasminogen activator detected in these patients’ sera.

It is suggested that decreased fibrinolysis aggravates the thrombotic episodes frequently encountered in Behçet’s disease; accordingly treatment with fibrinolytic agents was found to offer marked benefits.

 

  • References

  • 1 Alkjaersig N, Fletcher A. P, Sherry S. 1959; The mechanism of clot dissolution by plasmin. Journal of Clinical Investigation 38: 1086.
    CrossrefPubMedSearch in Google Scholar
  • 2 Bachman F, Duckert F, Koller F. 1958; Stewart-Prower factor assay and its clinical significance. Thrombosis et Diathesis Haemorrhagiea (Stuttgart) 02: 24.
    PubMedSearch in Google Scholar
  • 3 Behçet H. 1937; Über rezidivierendes, apthose, durch ein Virus verursachte Geschwüre am Mund, am Auge und an den Genitalien. Dermatologische Wochenschrift 105: 1157.
    PubMedSearch in Google Scholar
  • 4 Biggs R, Macfarlane R. G. 1962. Human Blood Coagulation and its Disorders. T. A. Davis Company, Philadelphia; 389.
    Search in Google Scholar
  • 5 Bol J, Dalgaard J. B, Scott D. 1958; Mucocutaneous - ocular syndrome with intestinal involvement : A clinical and pathological study of four fatal cases. American Journal of Medicine 25: 857.
    CrossrefPubMedSearch in Google Scholar
  • 6 Boolukos P. 1960; Phlebitiden und Thrombosen grober Körpervenen als Begleiterscheinungen der Behçet’schen Krankheit. Helvetica Medica Acta 27: 264.
    PubMedSearch in Google Scholar
  • 7 Chajek T, Fainaru M. 1973; Behcet’s disease with superior vena cava occlusion associated with decreased fibrinolysis. British Medical Journal 01: 782.
    CrossrefPubMedSearch in Google Scholar
  • 8 Curth H. D. 1946; Behcet’s syndrome, abortive form ( ?) (recurrent aphthous oral lesions and recurrent genital ulcerations). Archives of Dermatology 54: 481.
    PubMedSearch in Google Scholar
  • 9 Dowling G. B, Dudgeon G. A, Perkius E. S. 1961; Discussion on Behcet’s disease. Proceedings of Royal Society of Medicine 54: 101.
    PubMedSearch in Google Scholar
  • 10 Enoch B. A, Khoo T. C. L, Castillo J. L.Olivares, Grainger R. G, Henry L. 1968; Major vascular complications in Behçet’s syndrome. Postgraduate Medical Journal 44: 453.
    CrossrefPubMedSearch in Google Scholar
  • 11 Fearnley G. R, Balmforth G, Fearnley E. 1957; Evidence of a diurnal fibrinolytic rhythm with a simple method of measuring natural fibrinolysis. Clinical Science 16: 645.
    PubMedSearch in Google Scholar
  • 12 Haim S, Sherf K. 1969; Behçet’s disease : Presentation of 11 cases and evaluation of treatment. Israel Journal of Medical Sciences 02: 69.
    PubMedSearch in Google Scholar
  • 13 Hardisty R. M, Macpherson J. C. 1962; One-stage factor VIII (anti haemophilic globulin) assay and its use on venous and capillary plasma. Thrombosis et Diathesis Haemor- rhagica (Stuttgart) 07: 215.
    PubMedSearch in Google Scholar
  • 14 Hardisty R. M, Ingram G. I. C. 1965. Bleeding Disorders, Investigation and Management. T. A. Davis Company: Philadelphia; 307.
    Search in Google Scholar
  • 15 Izak G, Galewski K, Eyal Z. 1967; Studies on hypercoagulable state. Thrombosis et Diathesis Haemorrhagiea (Stuttgart) 18: 544.
    PubMedSearch in Google Scholar
  • 16 Izak G, Galewski K. 1966; Studies on experimentally induced hypercoagulable state in rabbits. Thrombosis et Diathesis Haemorrhagiea 16: 228.
    PubMedSearch in Google Scholar
  • 17 Katzenellenbogen I. 1950; Behçet’s syndrome. Archives of Dermatology 51: 418.
    PubMedSearch in Google Scholar
  • 18 Koller F, Loeliger A, Duckert F. 1951; Experiments on a new clotting factor. Acta Haematologica 06: 1.
    CrossrefPubMedSearch in Google Scholar
  • 19 Lee R. I, White P. D. 1955; A clinical study of the coagulation time of blood. American Journal of Medical Science 145: 495.
    PubMedSearch in Google Scholar
  • 20 Merskey C, Kleiner G. J, Johnson A. J. 1966; Quantitative estimation of split products of fibrinogen in human serum, relation to diagnosis and treatment. Blood 28: 1.
    PubMedSearch in Google Scholar
  • 21 Nazzaro P. 1966. Cutaneous manifestation of Behçet’s disease. In: Monacelli M, Nazzaro P. S. (eds.), Symposium on Behçefs Disease. Rome, Karger, A. G: Basel, Switzerland; 15.
    Search in Google Scholar
  • 22 Nilsson I. M, Krook H, Sternby N. H, Söderberg E, Söderstrong N. 1961; Severe thrombotic disease in a young man with bone marrow and skeletal changes and with a high content of an inhibitor in the fibrinolytic system. Acta Medica Scandinavia 169: 323.
    PubMedSearch in Google Scholar
  • 23 Quick A. T. 1951. The Physiology and Pathology of Haemostasis. Lea and Febiger: Philadelphia; 125.
    Search in Google Scholar
  • 24 Ratnoff O. D, Menzie C. 1951; A new method for the determination of fibrinogen in small samples of plasma. Journal of Laboratory and Clinical Medicine 37: 316.
    PubMedSearch in Google Scholar
  • 25 Shanberge J. N, Matsuaka T, Fauktjj H. 1967; A simple method for the preparation of a substrate for a one stage factor. Technical Bulletin, Regional Medical Technology 37: 67.
    PubMedSearch in Google Scholar
  • 26 Strachan R. W, Wigzell F. W. 1963; Polyarthritis in Behçet’s multiple symptom complex. Annals Rheumatic Diseases 22: 26.
    CrossrefPubMedSearch in Google Scholar
  • 27 Tomas E. W. P. 1947; So-called triple-symptom complex of Behçet. British Medical Journal 04: 14.
    PubMedSearch in Google Scholar
  • 28 von Kaulla K. N. 1958; A new method : Method for evaluation of human fibrinolysis. American Journal of Clinical Pathology 29: 104.
    CrossrefPubMedSearch in Google Scholar
  • 29 Wolf S. M, Schotland D. L, Phillips L. L. 1965; Involvement of nervous system in Behçet’s syndrome. Archives of Neurology 12: 315.
    CrossrefPubMedSearch in Google Scholar