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Thromb Haemost 1976; 36(03): 628-633
DOI: 10.1055/s-0038-1648083
Original Article
Schattauer GmbH

Effect of Aspirin on Platelet Phospholipids

J Valles
1   Department of Clinical Pathology (Head: Dr. J. Aznar), Ciudad Sanitaria “La Fe”, Valencia, Spain
,
J Aznar
1   Department of Clinical Pathology (Head: Dr. J. Aznar), Ciudad Sanitaria “La Fe”, Valencia, Spain
,
M. T Santos
1   Department of Clinical Pathology (Head: Dr. J. Aznar), Ciudad Sanitaria “La Fe”, Valencia, Spain
› Author Affiliations
Further Information

Publication History

Received 19 October 1975

Accepted 06 July 1976

Publication Date:
03 July 2018 (online)

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Summary

It was observed that the acetylsalicylic acid “in vitro” (final concentration 10−4 M) as well as “in vivo” (1 g of aspirin) caused a platelet phospholipids variation which basically consisted of:

1. A diminution of the phospholipids/proteins rate of 22%.

2. A reduction of sphingomyelin “in vivo” of 27.66% and “in vitro” of 16.82%.

3. An increase in phosphatidyl choline “in vivo” of 12.24% and “in vitro” 10.28%.

The possible effects that these changes might have on the platelet function are evaluated.

 

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