Thromb Haemost 1976; 36(01): 157-164
DOI: 10.1055/s-0038-1648020
Original Article
Schattauer GmbH

Low-Dose Heparin and Deep-Vein Thrombosis after Total Hip Replacement

P. M Mannucci
1  Haemophilia and Thrombosis Centre Angelo Bianchi Bonomi, University of Milano, 3rd Institute of Clinical Medicine, University of Milano; Orthopedic Hospital Gaetano Pini, Milano, Italy
,
Luisa E. Citterio
1  Haemophilia and Thrombosis Centre Angelo Bianchi Bonomi, University of Milano, 3rd Institute of Clinical Medicine, University of Milano; Orthopedic Hospital Gaetano Pini, Milano, Italy
,
N Panajotopoulos
1  Haemophilia and Thrombosis Centre Angelo Bianchi Bonomi, University of Milano, 3rd Institute of Clinical Medicine, University of Milano; Orthopedic Hospital Gaetano Pini, Milano, Italy
› Author Affiliations
Further Information

Publication History

Received 20 December 1975

Accepted 28 February 1976

Publication Date:
03 July 2018 (online)

Summary

The effect of subcutaneous low-dose heparin on postoperative deep-vein thrombosis (D. V. T.) (diagnosed by the 125I-labelled fibrinogen test) has been investigated in a trial of 143 patients undergoing the operation of total hip replacement. Two randomized studies were carried out: in one the scanning for D.V.T. was carried out daily for 7 days post operatively and in the other for 15 days. In both, the incidence of D.V.T. was significantly lower in the heparin-treated patients (P<0.005). Bilateral D.V.T. was also prevented (P<0.05), through the extension of D.V.T. to the distal veins of the thigh was not significantly reduced. Heparin treatment was, however, followed by a higher incidence of severe postoperative bleeding (P< 0.02) and wound haematoma formation (P< 0.005), and the postoperative haemoglobin was significantly lower than in the control group (P<0.005). A higher number of transfused blood units was also needed by the heparin treated patients (P<0.001).