Thromb Haemost 1976; 36(01): 086-089
DOI: 10.1055/s-0038-1648012
Original Article
Schattauer GmbH

Failure of Immunosuppression in a Severe Haemophilia B Patient with Specific Antibody

Jean-Pierre Allain
1  Centre pour Enfants hémophiles, Croix-Rouge Française, F 78940 La Queue-les-Yvelines and the Unité 56 de l’I.N.S.E.R.M., Hôpital d’Enfants, F 94270 Bicêtre.
,
Dominique Frommel
1  Centre pour Enfants hémophiles, Croix-Rouge Française, F 78940 La Queue-les-Yvelines and the Unité 56 de l’I.N.S.E.R.M., Hôpital d’Enfants, F 94270 Bicêtre.
› Author Affiliations
Further Information

Publication History

Received 30 March 1976

Accepted 12 April 1976

Publication Date:
03 July 2018 (online)

Summary

Prevention of a secondary response to factor IX by cyclophosphamide was attempted in an 11 year old patient with severe Christmas disease. An antibody to factor IX had been present for 4 years before immunosuppressive therapy was tried. Despite profound lymphopenia, synthesis of factor IX antibody was not depressed. The difficulties of modifying the anamnestic response to factor IX by chemical immunosuppression may be as real as has been reported for factor VIII in classical haemophilia.