Thromb Haemost 1976; 36(01): 009-013
DOI: 10.1055/s-0038-1648004
Original Article
Schattauer GmbH

Comparison of the Actions of Thrombin and the Thrombin-Like Venom Enzymes Ancrod and Batroxobin

D. L Aronson
1  Bureau of Biologics, Food and Drug Administration, Bethesda, Maryland 20014
› Author Affiliations
Further Information

Publication History

Received 23 February 1976

Accepted 26 February 1976

Publication Date:
03 July 2018 (online)

Summary

Thrombin acts on several coagulant proteins to produce products with physiologic, pharmacologic and pathologic potential. The most sensitive thrombin substrate seems to be factor VIII. Some thrombin dependent reactions studied in vitro and proposed as control reactions seem too insensitive to the action of thrombin to be of in vivo significance.

The only enzymic reaction the thrombin-like venom enzymes, Ancrod and Batroxobin, have in common with thrombin is the removal of fibrinopeptide A.