Thromb Haemost 1976; 35(01): 178-185
DOI: 10.1055/s-0038-1647942
Original Article
Schattauer GmbH

Studies on the Thromboplastic Effect of Human Plasma Lipoproteins

Helena Sandberg
1   From AB KABI, Research Department, Biochemistry, Fack S-104 25 Stockholm, Sweden
,
Lars-Olov Andersson
1   From AB KABI, Research Department, Biochemistry, Fack S-104 25 Stockholm, Sweden
› Author Affiliations
Further Information

Publication History

Received 30 June 1975

Accepted 10 August 1975

Publication Date:
02 July 2018 (online)

Summary

Human plasma lipoprotein fractions were prepared by flotation in the ultracentrifuge. Addition of these fractions to platelet-rich, platelet-poor and platelet-free plasma affected the partial thromboplastin and Stypven clotting times to various degrees. Addition of high density lipoprotein (HDL) to platelet-poor and platelet-free plasma shortened both the partial thromboplastin and the Stypven time, whereas addition of low density lipoprotein and very low density lipoprotein (LDL + VLDL) fractions only shortened the Stypven time. The additions had little or no effect in platelet-rich plasma.

Experiments involving the addition of anti-HDL antibodies to plasmas with different platelet contents and measuring of clotting times produced results that were in good agreement with those noted when lipoprotein was added. The relation between structure and the clot-promoting activity of various phospholipid components is discussed.

 
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