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Thromb Haemost 1976; 35(02): 415-422
DOI: 10.1055/s-0038-1647936
Original Article
Schattauer GmbH

Blood Coagulation and Fibrinolysis in Thyroid Disease

Nadir R. Farid
1   General Hospital and The Faculty of Medicine Memorial University of Newfoundland St. John’s, Newfoundland, Canada A1C 5S7
,
Brian L. Griffiths
1   General Hospital and The Faculty of Medicine Memorial University of Newfoundland St. John’s, Newfoundland, Canada A1C 5S7
,
John R. Collins
1   General Hospital and The Faculty of Medicine Memorial University of Newfoundland St. John’s, Newfoundland, Canada A1C 5S7
,
William H. Marshall
1   General Hospital and The Faculty of Medicine Memorial University of Newfoundland St. John’s, Newfoundland, Canada A1C 5S7
,
David Wallace Ingram
1   General Hospital and The Faculty of Medicine Memorial University of Newfoundland St. John’s, Newfoundland, Canada A1C 5S7
› Author Affiliations
Further Information

Publication History

Received 11 June 1975

Accepted 12 August 1975

Publication Date:
02 July 2018 (online)

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Summary

Fibrinolytic activity and factor VIII concentration were studied in 30 patients with moderate to minimal hypothyroidism and in 7 patients with hyperthyroidism. In the hypothyroid group, the results were related to serum thyroxine levels, HL-A phenotypes and thyroid autoantibody titres. As serum thyroxine decreased so did factor VIII concentration, however, euglobulin lysis time was correspondingly prolonged. Factor VIII appears to be the most sensitive among coagulation factors to the deterioration of thyroid function tests. There was a significant correlation between the reciprocal of thyroid antibody titres and fibrinolysis; however, there was no relationship between factor VIII concentration or fibrinolysis and a specific HL-A phenotype although the incidence of HL-A8 was increased in the group as a whole.

Euglobulin lysis time was prolonged in 6 out of 7 patients with Graves’ hyperthyroidism. Factor VIII was elevated in only 3 of these patients.

 

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