Thromb Haemost 1976; 35(02): 324-333
DOI: 10.1055/s-0038-1647925
Original Article
Schattauer GmbH

Studies on Chemically Modified Fibrinogen

M Kloczewiak
1   Department of Medicine, Justus Liehig University Gießen, Gießen, Germany BRD and Department of Radiology and Health Protection Institute of Nuclear Research, Warsaw, Poland.
,
Z Wegrzynowicz
1   Department of Medicine, Justus Liehig University Gießen, Gießen, Germany BRD and Department of Radiology and Health Protection Institute of Nuclear Research, Warsaw, Poland.
,
F.R Matthias
1   Department of Medicine, Justus Liehig University Gießen, Gießen, Germany BRD and Department of Radiology and Health Protection Institute of Nuclear Research, Warsaw, Poland.
,
D.L Heene
1   Department of Medicine, Justus Liehig University Gießen, Gießen, Germany BRD and Department of Radiology and Health Protection Institute of Nuclear Research, Warsaw, Poland.
,
Maria Zajdel
1   Department of Medicine, Justus Liehig University Gießen, Gießen, Germany BRD and Department of Radiology and Health Protection Institute of Nuclear Research, Warsaw, Poland.
› Author Affiliations
Further Information

Publication History

Received 28 June 1975

Accepted 10 October 1975

Publication Date:
02 July 2018 (online)

Summary

Treatment of fibrinogen with maleic acid anhydride renders fibrinogen unclottable depending on the degree of modification of the molecule. According to radioactive studies the release of fibrinopeptides by thrombin or reptilase is undisturbed. The incoagulability is due to inhibition of the polymerization process of fibrinmonomers derived from modified fibrinogen, mainly caused by the increase of electronegative charges upon the fibrinogen molecule. According to discelectrophoretic analysis modified fibrinogen fails to produce fragments D and E following plasmic digestion, however, may be degraded to high molecular weight products. Modified fibrinogen reveals some similarities to abnormal fibrinogens in congenital dysfibrinogenemia with regard to its functional properties.

 
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