Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1975; 33(03): 610-616DOI: 10.1055/s-0038-1647856 International Committee on Thrombosis and Haemostasis Task Force Schattauer GmbH Post-transfusion Hepatitis Following the Use of Prothrombin Complex Concentrates[*] [**] Harold R Roberts 1 Departments of Medicine and Pathology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina 27514 , Philip M Blatt 1 Departments of Medicine and Pathology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina 27514› Author AffiliationsRecommend Article Abstract Buy Article Summary The incidence of post-transfusion hepatitis in patients receiving concentrates containing the prothrombin complex factors is reviewed. A survey of the literature indicates a high incidence of hepatitis in such patients. Full Text References References 1 Allain J. P, Soulier J. P. Personal communication. 1974 2 Barker L. F, Schulman N. P, Murray P, Hirschman R. J, Ratner F, Diefenbach W. C. L, Geller H. M. Transmission of serum hepatitis. Journal of the American Medical Association 1970; 211: 1509 3 Biggs R. Jaundice and antibodies directed against factor VIII and IX in patients treated for haemophilia or Christmas disease in the United Kingdom. British Journal of Haematology 1974; 26: 313 4 Blatt P. M, Lundblad R. L, Kingdon H. S, McLean G, Roberts H. R. Thrombogenic material in prothrombin complex concentrates. Annals of Internal Medicine 1974; 81: 766 5 Bryan J. A, Brett C. B, Roberts H. R. Experience with serum hepatitis in a hemophilic population. Clinical Research 1969; 17: 29 6 Faria R, Fiumara N. J. Hepatitis associated with Konӯne. New England Journal of Medicine 1972; 287: 358 7 Grammens G. L, Breckenridge R. T. Complications with Christmas factor (factor IX) concentrates. Annals of Internal Medicine 1974; 80: 666 8 Hoofnagle J. H, Aronson D. L, Roberts H. R. Serologic evidence for hepatitis B virus infection in patients with hemophilia B. Thrombosis et Diathesis Haemorrhagica 1975; 33: 606 9 Hoofnagle J. H, Gerety R. J, Ni L. Y, Barker L. F. Antibody to hepatitis B core antigen : a sensitive implicator of hepatitis B virus replication. New England Journal of Medicine 1974; 290: 1336 10 Johnson A. J, Newman J, Semar M, Middleton S. H, Smith J. K. Removal of hepatitis-B antigen (HBAg) from coagulation factor II, VII, IX and X concentrates for clinical use. IVth International Congress on Thrombosis and Haemostasis,Vienna,Austria, Abstracts. 1973 11 Johnson A. J. Concentration of hepatitis B antigen from clinical preparations of II, VII, IX and X by polyethylene glycol to enhance detection and removal. Annals of the New York Academy of Sciences in press. 1975 12 Kasper C, Kipnis S. Hepatitis and clotting factor concentrates. The Journal of the American Medical Association 1972; 221: 510 13 Krugman S, Hoofnagle J. H, Gerety R. J, Kaplan P. M, Gerin J. L. Viral hepatitis B: DNA polymerase activity, and antibody core antigen. New England Journal of Medicine 1974; 290: 1331 14 Le Bovier G. L. The heterogeneity of Australia antigen. Journal of Infectious Diseases 1971; 123: 671 15 Melnick J. L, Hollinger F. B. Hepatitis virology. Progress in Liver Diseases 1972; 4: 345 16 Ménaché D. Factor IX concentrates. Thrombosis et Diathesis Haemorrhagica 1975; 33: 600 17 Murray T. Viral hepatitis. Bulletin of the New York Academy of Medicine 1955; 31: 341 18 Nilsson I. M. Personal communication. 1974 19 Prince A. M, Brotman B, Grady G. F, Kruhns W. J, Hazzi C, Levine R. W, Millian S. J. Long incubation post-transfusion hepatitis without serology. Lancet 1974; 2: 241 20 Sandler S. G, Rath C. E, Ruder A. Prothrombin complex concentrate in acquired hypoprothrombinemia. Annals of Internal Medicine 1973; 79: 485
