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Thromb Haemost 1974; 32(02/03): 608-616
DOI: 10.1055/s-0038-1647730
Original Article
Schattauer GmbH

Rapid Detection and Quantitation of Precipitating Streptokinase-Antibodies

F Spöttl
1   Department of Internal Medicine (Head: Doz. Dr. F. Spöttl), Allgemeines, Öffentliches Krankenhaus Schärding, Austria
,
R Kaiser
1   Department of Internal Medicine (Head: Doz. Dr. F. Spöttl), Allgemeines, Öffentliches Krankenhaus Schärding, Austria
› Author Affiliations
Further Information

Publication History

Received 17 June 1974

Accepted 25 July 1974

Publication Date:
24 July 2018 (online)

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Summary

Streptokinase-therapy is regularly followed by a marked increase of precipitating streptokinase-antibodies. These antibodies cause a significant inhibition of streptokinase-induced plasminogen activation. Counterelectrophoresis is a useful method of tracing the antibodies in serum. For quantitative estimation a modified radial immunodiffusion method is presented. The antibodies were identified as IgG.

 

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