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Thromb Haemost 1974; 32(02/03): 284-291
DOI: 10.1055/s-0038-1647699
Original Article
Schattauer GmbH

Effect of Dextran on Experimental Venous Thrombosis in Rabbits

A.-K Ah-See
1   Department of Experimental Medicine, Pharmacia AB and Department of Surgery, University Hospital, Uppsala, Sweden, and Department of Surgery, University of Aberdeen, Aberdeen, Scotland
,
K.-E Arfors
1   Department of Experimental Medicine, Pharmacia AB and Department of Surgery, University Hospital, Uppsala, Sweden, and Department of Surgery, University of Aberdeen, Aberdeen, Scotland
,
D Bergqvist
1   Department of Experimental Medicine, Pharmacia AB and Department of Surgery, University Hospital, Uppsala, Sweden, and Department of Surgery, University of Aberdeen, Aberdeen, Scotland
,
O Tangen
1   Department of Experimental Medicine, Pharmacia AB and Department of Surgery, University Hospital, Uppsala, Sweden, and Department of Surgery, University of Aberdeen, Aberdeen, Scotland
› Author Affiliations
Further Information

Publication History

Received 05 November 1973

Accepted 20 June 1974

Publication Date:
30 June 2018 (online)

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Summary

An experimental model combining controlled stasis and endothelial destruction by sodium morrhuate has been used to investigate the effect of dextran on venous thrombus formation in rabbits. Dextran 70 (1 g/kg body weight in a 10% solution), given 3 hours before thrombosis induction, significantly reduced the incidence of venous thrombosis when compared to a saline control. Dextran 40 (1 g/kg body weight in a 10% solution) and dextran 70 (0.6 g/kg body weight in a 6% solution) had no significant effect under these conditions. When given 10 or 120 minutes before initiation of thrombosis none of the dosages of dextran had any preventive effect. The results indicate that the haemodynamic effects of dextran were not involved in its preventive effect in this study. The effect of dextran was probably due to a combination of an effect on platelet reactivity and a change of the structure of fibrin formed during growth of the thrombi.

 

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