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Thromb Haemost 1974; 32(01): 189-202
DOI: 10.1055/s-0038-1647684
Original Article
Schattauer GmbH

Effect of Induced Chronic Intravascular Coagulation on Plasminogen Activator in Dogs

Nora C. J. Sun
1   Mayo Clinic and Mayo Foundation Rochester, Minnesota, U.S.A
,
E. J Walter Bowie
1   Mayo Clinic and Mayo Foundation Rochester, Minnesota, U.S.A
,
Jack L. Titus
1   Mayo Clinic and Mayo Foundation Rochester, Minnesota, U.S.A
,
Charles A. Owen Jr.
1   Mayo Clinic and Mayo Foundation Rochester, Minnesota, U.S.A
› Author Affiliations
Further Information

Publication History

Received for publication 21 January 1974

Accepted for publication 20 May 1974

Publication Date:
30 June 2018 (online)

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Summary

Plasminogen activator activity in blood vessels of various organs was determined in three untreated (control) male dogs and in two male dogs that received a continuous infusion of canine brain thromboplastic emulsion for 2 weeks. Activator was measured by the speed and degree of lysis of fibrin films that were overlaid with slices of tissue. Depletion of vascular plasminogen activator occurred in the vena cava of treated dogs at the site of the tip of the catheter, which was surrounded by a clot. A decrease of activator was found in most organs and particularly in certain endocrine organs (thyroid, pituitary, and testis). Of organs that normally contained the most activator, the greatest depletion was found in the skin, lung, and penis. The wide variation of plasminogen activator activity in organs of normal dogs is described.

 

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