Thromb Haemost 1974; 32(01): 071-078
DOI: 10.1055/s-0038-1647674
Original Article
Schattauer GmbH

On the Antithrombotic Action of Heparin[*]

Stanford Wessler
Department of Medicine, The Jewish Hospital of St. Louis and the Washington University School of Medicine, St. Louis, Missouri, U.S.A
,
E Thye Yin
Department of Medicine, The Jewish Hospital of St. Louis and the Washington University School of Medicine, St. Louis, Missouri, U.S.A
› Author Affiliations
Further Information

Publication History

Received 03 June 1974

Accepted after resubmission 03 June 1974

Publication Date:
30 June 2018 (online)

 

* Presented at the American Society of Hematology Meeting, Chicago, December 1. 1973.


 
  • References

  • 1 Bauer G. 1954. Proceedings of the 1st International Conference on Thromboembolism. B. Schwabe; Basel: 721.
  • 2 Best C. H. 1948. In: Blood Clotting and Allied Problems. Josiah Jr M. a.cy. Foundation; New York: 26.
  • 3 Biggs R, Denson K WE, Akman N, Borrett R, Hadden M. 1970; Antithrombin III antifactor Xa and heparin. British Journal of Haematology 19: 283.
  • 4 Detakats G. 1950; Anticoagulants in surgery. Journal of the American Medical Association 142: 527.
  • 5 Deykin D. 1968; Hepatic removal of activated Factor X by the perfused rabbit liver. American Journal of Physiology 214: 414.
  • 6 Gurewich V, Thomas D. P, Stein M, Wessler S. 1963; Bronchoconstriction in the presence of pulmonary embolism. Circulation 27: 339.
  • 7 Jevons S, Barton P. G. 1971; Biochemistry of blood platelets. I. Interaction of activated Factor X with platelets. Biochemistry (Seattle) 10: 428.
  • 8 Leggenhager K. 1957; Genese und Prophylaxis der postoperativen Fernthrombose. Helvetica chirurgica acta 24: 316.
  • 9 Marciniak E. 1973; Factor-Xa inactivation by antithrombin III. Evidence for biological stabilization of Factor Xa by Factor Y-phospholipid complex. British Journal of Haematology 24: 391.
  • 10 Marciniak E, Tsueamura S. 1972; Two progressive inhibitors of Factor Xa in human blood. British Journal of Haematology 22: 341.
  • 11 Marcus A. J, Zucker M. B. 1965. The Physiology of Blood Platelets. Grune and Stratton. New York: 21.
  • 12 Rosenberg R. D, Damus Paul S. 1973; The purification and mechanism of action of human antithrombin-heparin cofactor. Journal of Biological Chemistry 248: 6490.
  • 13 Seegers W. H. 1968; Antithrombin on proteinase inhibitor. Annals of the New York Academy of Sciences 146: 593.
  • 14 Seegers W. H, Cole E. R, Hatmison C. R, Monkhouse F. C. 1964; Neutralization of autoprothrombin C activity with antithrombin. Canadian Journal of Biochemistry 42: 359.
  • 15 Seegers W. H, Marciniak E. 1962; Inhibition of autoprothrombin C activity with plasma. Nature (Lond.) 193: 1188.
  • 16 Sharnoff J. G. 1966; Results in the prophylaxis of postoperative thromboembolism. Surgical Gynaecology and Obstetrics 123: 303.
  • 17 Spaet T. H, Kropatkin M. 1957; Effect of intrasinous soy bean phosphatides on blood coagulation in rabbits. Proceedings of the Society for Experimental Biology 95: 492.
  • 18 Surgenor D. M, Wallach D. F.H. 1961. Biophysical Aspects of Platelet Reaction Mechanisms in Clotting. In: Johnson S. A, Monto R. W, Rebuck J. W. , Horn Jr. R. C. (eds.) Blood Platelets, Little: Brown, Boston; 289.
  • 19 Thomas D. P, Stein M, Tanabe G, Rege V, Wessler S. 1964; Mechanism of bronchoconstriction produced by thromboemboli in dogs. American Journal of Pysio- logy 206: 1207.
  • 20 Thomas D. P, Wessler S. 1964; Stasis thrombi induced by bacterial endotoxin. Circulation Research 14: 486.
  • 21 Wessler S. 1953; Studies in intravascular coagulation. II. A comparison of the effect of dicumarol and heparin on clot formation in isolated venous segments. Journal of Clinical Investigation 32: 650.
  • 22 Wessler S, Fischbein J. W. 1954; An improved method for the intravenous administration of heparin: its clinical application. New England Journal of Medicine 250: 860.
  • 23 Wessler S, Morris L. E. 1955; Studies in intravascular coagulation. IV. The effect of heparin and dicumarol on serum-induced venous thrombosis. Circulation 12: 553.
  • 24 Wessler S, Yin E. T. 1973; The theory and practice of mini-dose heparin in surgical patients: a status report. Circulation 47: 671.
  • 25 Yin E. T, Guidice L. C, Wessler S. 1973a Inhibition of activated Factor X- induced platelet aggregation : the role of heparin and the plasma inhibitor to activated Factor X. Journal of Laboratory and Clinical Medicine 81: 298.
  • 26 Yin E. T, Wessler S, Butler J. V. 1973b Plasma heparin: a unique practical, submicrogram-sensitive assay. Journal of Laboratory and Clinical Medicine 81: 298.
  • 27 Yin E. T, Wessler S. 1968; Investigation of the apparent thrombogenicity of thrombin. Thrombosis et Diathesis Haemorrhagica 20: 465.
  • 28 Yin E. T, Wessler S. 1969; Evidence for a naturally occurring plasma inhibitor of activated Factor X: its isolation and partial purification. Thrombosis et Diathesis Haemorrhagica 21: 398.
  • 29 Yin E. T, Wessler S. 1970; Heparin-accelerated inhibition of activated Factor X by its natural plasma inhibitor. Biochemica Biophysica Acta 201: 387.
  • 30 Yin E. T, Wessler S, Stoll P. J. 1971a Biological properties of the naturally- occurring plasma inhibitor to activated Factor X. Journal of Biological Chemistry 246: 3703.
  • 31 Yin E. T, Wessler S, Stoll P. J. 1971b Identity of plasmaactivated Factor X inhibitor with antithrombin III and heparin cofactor. Journal of Biological Chemistry 246: 3712.
  • 32 Yin E. T, Wessler S, Stoll P. J. (1971 c) Rabbit plasma inhibitor of the activated species of blood coagulation Factor X. Purification and some properties. Journal of Biological Chemistry 246: 3694.