Summary
The effects of four sulphated polysaccharides on bleeding time and lipase release
in rabbits have been compared. Unfractionated heparin (UFH) and pentosan polysulphate
both gave significant prolongation of bleeding times and high lipase release. Low
molecular weight heparin had reduced effects on bleeding time and lipase release,
while demialan sulphate had no influence on either parameter. There was a highly significant
correlation (r = 0.97) between these two measurements.
These results suggest that the same structural featuresinfluence both the haemorrhagic
and lipase-releasing properties of sulphated polysaccharides.
Keywords
Heparin - Lipase - Haemorrhage
