Am J Perinatol 2018; 35(S 01): S1-S26
DOI: 10.1055/s-0038-1646965
Abstracts
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Analysis of the Associations between Endothelial Nitric Oxide Synthase Gene Polymorphism and Arterial Hypotension in Premature Infants with Early-Onset Bacterial Infections

V. Pokhylko
1   Department of Pediatrics #1 with Propedeutics and Neonatology, Ukrainian Medical Stomatological Academy, Poltava, Ukraine
,
D. Dobryanskyy
2   Department of Pediatrics #2, Lviv National Medical University, Lviv, Ukraine
,
O. Kovalova
1   Department of Pediatrics #1 with Propedeutics and Neonatology, Ukrainian Medical Stomatological Academy, Poltava, Ukraine
,
O. Vorobiova
3   Department of Neonatology, Institute of Pediatrics, Obstetrics and Gynecology of NAMS Ukraine, Kyiv, Ukraine
,
Y. Cherniavska
1   Department of Pediatrics #1 with Propedeutics and Neonatology, Ukrainian Medical Stomatological Academy, Poltava, Ukraine
,
S. Tsvirenko
1   Department of Pediatrics #1 with Propedeutics and Neonatology, Ukrainian Medical Stomatological Academy, Poltava, Ukraine
,
H. Soloviova
1   Department of Pediatrics #1 with Propedeutics and Neonatology, Ukrainian Medical Stomatological Academy, Poltava, Ukraine
› Author Affiliations
Further Information

Publication History

Publication Date:
27 April 2018 (online)

 

Introduction: Perinatal infections and neonatal sepsis rank among the most frequent causes of mortality in the neonatal intensive care units (NICUs). Septic shock is often the final cause of death and severe complications appear in newborns who develop sepsis. It is known that the endothelium regulates vascular tone through the release of vasodilating and vasoconstricting factors. Nitric oxide (NO) is the endothelial dilation factor and is formed with the participation of the endothelial NO synthase (eNOS). The aim of our study was to examine the influence of eNOS gene polymorphism on the development of arterial hypotension in premature infants with early-onset infections.

Materials and Methods: This is a prospective observational study that included 118 preterm infants with early-onset infections (n = 57 with arterial hypotension and n = 61 without arterial hypotension) admitted to the NICUs of children’s hospitals of Poltava region, Ukraine. Genotyping was performed in both groups to determine the 4a/4b polymorphism of the eNOS gene. A comparison of clinical, laboratory, instrumental indices in prematurely born children with arterial hypotension and 4a/4a, 4a/4b, 4b/4b genotypes of the eNOS gene was performed. An analysis of associations between different genotypes of the eNOS gene and the development of arterial hypotension in prematurely born children was also conducted.

Results and Discussion: The distribution of newborns in three polymorphic variants of the eNOS gene 4a/4b polymorphism was identical among the groups under study: with arterial hypotension—0, 56.25, and 43.75%; in children without arterial hypotension—3.88, 63.73, and 32.35%, p = 0.577, p = 0.235, and p = 0.422. In addition, the analysis of several demographic, clinical, echocardiographic parameters did not reveal significant associations with variants of genotype of eNOS.

Conclusion: Based on our data, the 4a/4b polymorphism of the eNOS gene does not affect the occurrence of hemodynamic disorders in prematurely born children with early-onset infections.

Keywords: premature infants, early-onset infections, arterial hypotension, eNOS gene, 4a/4b polymorphism