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Thromb Haemost 1979; 41(03): 537-543
DOI: 10.1055/s-0038-1646806
Original Articles
Schattauer GmbH Stuttgart

Prevention of Intravascular Thrombus Formation on Plastic Catheters with Heparin-Benzalkonium Complex: in Vivo and in Vitro Studies

Roger W Evans
The Division of Hematology–Oncology, Department of Medicine, Cornell University Medical College, the Clinical Investigation Service, Cardiology and Pathology Services, Tripler Army Medical Center, and the Gunderson Clinic
,
Mark W Pasmantier
The Division of Hematology–Oncology, Department of Medicine, Cornell University Medical College, the Clinical Investigation Service, Cardiology and Pathology Services, Tripler Army Medical Center, and the Gunderson Clinic
,
Morton Coleman
The Division of Hematology–Oncology, Department of Medicine, Cornell University Medical College, the Clinical Investigation Service, Cardiology and Pathology Services, Tripler Army Medical Center, and the Gunderson Clinic
,
Franklin S Wagner
The Division of Hematology–Oncology, Department of Medicine, Cornell University Medical College, the Clinical Investigation Service, Cardiology and Pathology Services, Tripler Army Medical Center, and the Gunderson Clinic
,
Robert C Flair
The Division of Hematology–Oncology, Department of Medicine, Cornell University Medical College, the Clinical Investigation Service, Cardiology and Pathology Services, Tripler Army Medical Center, and the Gunderson Clinic
› Author Affiliations
Further Information

Publication History

Received 30 March 1977

Accepted 26 May 1978

Publication Date:
09 July 2018 (online)

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Summary

A complex of heparin and a quaternary ammonium compound dissolved in an organic solvent was investigated for its potential ability to prevent clotting on the surface of plastic catheters. Despite the complexing of heparin to ammonium, anticoagulant activity remained on in vitro testing. Both the heparin complex and its organic solvent alone partially prevented catheter thrombus formation when tested in an in vivo animal model system. Neither, however, was totally effective in preventing thrombosis.

 

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