Prevention of Intravascular Thrombus Formation on Plastic Catheters with Heparin-Benzalkonium Complex: in Vivo and in Vitro Studies

Roger W Evans; Mark W Pasmantier; Morton Coleman; Franklin S Wagner; Robert C Flair

doi:10.1055/s-0038-1646806

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1979; 41(03): 537-543
DOI: 10.1055/s-0038-1646806

Original Articles

Schattauer GmbH Stuttgart

Prevention of Intravascular Thrombus Formation on Plastic Catheters with Heparin-Benzalkonium Complex: in Vivo and in Vitro Studies

Roger W Evans

The Division of Hematology–Oncology, Department of Medicine, Cornell University Medical College, the Clinical Investigation Service, Cardiology and Pathology Services, Tripler Army Medical Center, and the Gunderson Clinic

,

Mark W Pasmantier

The Division of Hematology–Oncology, Department of Medicine, Cornell University Medical College, the Clinical Investigation Service, Cardiology and Pathology Services, Tripler Army Medical Center, and the Gunderson Clinic

,

Morton Coleman

The Division of Hematology–Oncology, Department of Medicine, Cornell University Medical College, the Clinical Investigation Service, Cardiology and Pathology Services, Tripler Army Medical Center, and the Gunderson Clinic

,

Franklin S Wagner

The Division of Hematology–Oncology, Department of Medicine, Cornell University Medical College, the Clinical Investigation Service, Cardiology and Pathology Services, Tripler Army Medical Center, and the Gunderson Clinic

,

Robert C Flair

The Division of Hematology–Oncology, Department of Medicine, Cornell University Medical College, the Clinical Investigation Service, Cardiology and Pathology Services, Tripler Army Medical Center, and the Gunderson Clinic

› Author Affiliations

Abstract

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Summary

A complex of heparin and a quaternary ammonium compound dissolved in an organic solvent was investigated for its potential ability to prevent clotting on the surface of plastic catheters. Despite the complexing of heparin to ammonium, anticoagulant activity remained on in vitro testing. Both the heparin complex and its organic solvent alone partially prevented catheter thrombus formation when tested in an in vivo animal model system. Neither, however, was totally effective in preventing thrombosis.

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References

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