Thromb Haemost 1978; 39(03): 657-662
DOI: 10.1055/s-0038-1646740
Original Article
Schattauer GmbH Stuttgart

Comparison of Factor VIII Levels after Adrenalin in Classic Hemophilia and von Willebrand’s Disease (vWd)[*]

M Elaine Eyster
1   The Division of Hematology, Departement of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, U.S.A.
,
James O Ballard
1   The Division of Hematology, Departement of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, U.S.A.
,
David Prager
1   The Division of Hematology, Departement of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, U.S.A.
› Author Affiliations
Further Information

Publication History

Received 19 October 1977

Accepted 22 November 1977

Publication Date:
26 July 2018 (online)

Summary

The factor VIII response to adrenalin was compared in 5 patients with von Willebrand’s disease (vWd) and 10 hemophiliacs with baseline factor VIII procoagulant activity (VIIIAHF) of 0.01 u/ml or greater. Patients with vWd showed a two-fold VIII AHF increase, while those with hemophilia showed no significant change 1 hr following the subcutaneous injection of adrenalin. These results suggest that the adrenalin stimulation test may be of value in distinguishing certain patients with mild hemophilia from those with vWd.

* Presented at the XII Congress of the World Federation of Haemophilia, New York, June 22-25, 1977


 
  • References

  • 1 Bennett B, Ratnoff OD. 1972; Changes in antihemophilic factor (AHF, factor VIII) procoagulant activity and AHF-like antigen in normal pregnancy and following exercise and pneumoencephalography. Journal of Laboratory and Clinical Medicine 80: 256
  • 2 Denson KWE. 1973; The detection of factor VIII-like antigen in haemophilia carriers and inpatients with raised levels of biologically active factor VIII. British Journal of Haematology 24: 451
  • 3 Egeberg O. 1963; Changes in the activity of antihemophilic A factor (F VIII) and in the bleeding time associated with muscular exercise and adrenalin infusion. Scandinavian Journal of Clinical and Laboratory Investigations 15: 539
  • 4 Eyster ME, Bowman HS, Ladda R. 1977; Carriers with excessively low factor VIII procoagulant activity (VIII AHF). a study of two unrelated families with mild hemophilia A. Blood 49: 607
  • 5 Eyster ME, Jones MB, Delli-Bovi L, Moore T. 1976; Carrier detection in classic hemophilia by combined measurement of immunologic (VIII AGN) and procoagulant (VIII AHF) activities. American Journal of Clinical Pathology 65: 975
  • 6 Iatridis SG, Ferguson JH. 1963; Effect of physical exercise on blood clotting and fibrinolysis. Journal of Applied Physiology 18: 337
  • 7 Ingram GIC. 1961; Increase in antihaemophilic globulin activity following infusion of adrenaline. Journal of Physiology 156: 217
  • 8 Ingram GIC. 1973. The control of the Factor VIII level in the non-haemophilic subject. In: Ala F, Denson KWE. (eds.) Haemophilia, Proceedings of the VII Congress of the World Federation of Haemophilia. 1971 Excerpta Medica; 3
  • 9 Ingram GIC, Jones RV. 1966; The rise in clotting Factor VIII induced in man by adrenalin. effect of α and β blockers. Journal of Physiology 187: 447
  • 10 Mannucci PM, Capitanio A, Ruggeri ZM. 1973. Stress, hormones and Factor VIII. In: Ala F, Denson KWE. (Eds.) Proceedings of the VII Congress of the World Federation of Haemophilia, 1971. Excerpta Medica; 11
  • 11 Mannucci PM, Pareti FI, Ruggeri ZM, Capitanio A. 1977; l-Deamino-8-D-arginine vasopressin. a new pharmacological approach to the management of haemophilia and von Willebrand’s disease. Lancet I: 869
  • 12 Niemetz J, Nossel HC. 1969; Activated coagulation factors. in vivo and in vitro studies. British Journal of Haematology 16: 337
  • 13 Prentice CRM, Forbes CD, Smith SM. 1972; Rise of factor VIII after exercise and adrenalin infusion, measured by immunological and biological techniques. Thrombosis Research 1: 493
  • 14 Rickles FR, Hoyer LW, Rich ME, Ahr DJ. 1976; The effects of epinephrine infusion in patients with von Willebrand’s disease. Journal of Clinical Investigation 57: 1618
  • 15 Rizza CR. 1961; Effect of exercise in the level of antihaemophilic globulin in human blood. Journal of Physiology 156: 128
  • 16 Weeke B. 1973; Crossed Immunoelectrophoresis. Scandinavian Journal of Immunology 2 Suppl 7 47
  • 17 Weiss HJ, Rogers J, Brand H. 1973; Defective ristocetin induced aggregation in von Willebrand’s disease and its correction by Factor VIII. Journal of Clinical Investigations 52: 2691
  • 18 Zimmerman JS, Ratnoff OD, Levin J. 1971; Immunologic differentiation of classic hemophilia and von Willebrand’s disease. Journal of Clinical Investigations 59: 244