The Value of Phenformin and Ethyloestrenol in the Prevention of Deep Venous Thrombosis in Patients Undergoing Surgery

Summary

The effect of phenformin and ethyloestrenol on the incidence of post-operative deep venous thrombosis was studied in 314 surgical patients in a double-blind randomised trial.

Although the laboratory tests suggested that the regime produced an increase in activators of the fibrinolytic system, the drugs used did not lower the incidence of post-operative deep venous thrombosis.

Possible explanations of this paradox are advanced.

• References

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