Download PDF
Thromb Haemost 1978; 39(01): 032-038
DOI: 10.1055/s-0038-1646651
Original Article
Schattauer GmbH Stuttgart

Catabolism of Fibrinogen in Pregnant Rabbits before and after Delivery

Ingo Mahn
Division of Clinical Immunology and Blood Transfusion, Central Division of the Department of Nuclear Research, and the Department of Medicine, Justus-Liebig-Universität, Giessen, West-Germany
,
Richard-Mathias Moeller
Division of Clinical Immunology and Blood Transfusion, Central Division of the Department of Nuclear Research, and the Department of Medicine, Justus-Liebig-Universität, Giessen, West-Germany
,
Gert Müller-Berghaus
Division of Clinical Immunology and Blood Transfusion, Central Division of the Department of Nuclear Research, and the Department of Medicine, Justus-Liebig-Universität, Giessen, West-Germany
› Author Affiliations
Further Information

Publication History

Received 13 April 1977

Accepted 24 June 1977

Publication Date:
12 July 2018 (online)

  PDF Download  Permissions and Reprints

Summary

16 nón-pregnant female and 19 pregnant rabbits were injected with purified rabbit 125I-fibrinogen in order to study the catabolism of fibrinogen before and after delivery. The half-life time (T ½) of the clottable 125I-radioactivity in pregnant rabbits during the last third of gestation was 27.3 ± 5.3 hr in comparison to 54.4 ± 3.7 hr in non-pregnant rabbits. After delivery, T ½ returned to normal values of 47.9 ± 10.9 hr. The fractional catabolic rate (FCR) of the clottable 125I-radioactivity was 67.1% × d−1 ± 8.6 before and 41.6% × d−1 after delivery whereas FCR in non-pregnant rabbits amounted to 44.7% × d−1 ± 4.8. These figures demonstrate a pronounced increase in fibrinogen catabolism during the last third of gestation in pregnant rabbits and a normalization immediately after delivery. Although in pregnant rabbits the elimination of fibrinogen from the circulating blood was pronouncedly increased, the plasma fibrinogen concentration did not change. Only after delivery did the fibrinogen concentration increase when the fibrinogen catabolism had already normalized.

 

  • References

  • 1 Beller FK, Douglas GW, Morris RH, Johnson AJ. 1968; The fibrinolytic enzyme system in pregnancy. A comparison between ovarian and antecubital blood. American Journal of Obstetrics and Gynecology 101: 587
    CrossrefPubMedGoogle Scholar
  • 2 Brakman P. 1966; The fibrinolytic system in human blood during pregnancy. American Journal of Obstetrics and Gynecology 94: 14
    CrossrefPubMedGoogle Scholar
  • 3 Chandra RK, Malkani PK, Bhasin K. 1973; Serum levels of α2-macroglobulin and IgG and cryofibrinogenemia in pregnancy. Obstetrics and Gynecology 41: 56
    PubMedGoogle Scholar
  • 4 Dost FH. 1953. Der Blutspiegel. Kinetik der Konzentrationsabläufe in der Kreislaüffliissigkeit. Georg Thieme Verlag; Leipzig:
    Google Scholar
  • 5 Glueck HI, Herrmann LG. 1964; Cold-precipitable fibrinogen, “cryofibrinogen”. Archives of Internal Medicine 113: 748
    CrossrefPubMedGoogle Scholar
  • 6 Graeff H, von Hugo R, Hafter R. 1973; In vivo formation of soluble fibrin monomer complexes in human plasma. Thrombosis Research 3: 465
    CrossrefPubMedGoogle Scholar
  • 7 Hafter R, schneebauer T, Tafel K, Ernst E, Graeff H. 1975; Bestimmung von löslichen Fi-brinmonomerkomplexen zur Erfassung der Hyperkoagulabilität in der Schwangerschaft und unter der Geburt. Geburtshilfe und Frauenheilkunde 35: 518
    PubMedGoogle Scholar
  • 8 Hahn L. 1974; On fibrinolysis and coagulation during parturition and menstruation. Acta Obstetrica et Gynecologica Scandinavica Suppl (Suppl. 28) 1
    PubMedGoogle Scholar
  • 9 Jacobsson K. 1955; Studies on fibrinogen. I. Studies on the determination of fibrinogen in human blood plasma. Scandinavian Journal of Clinical and Laboratory Investigation 7 Suppl (Suppl. 14) 1
    CrossrefPubMedGoogle Scholar
  • 10 Kitzmiller JL, Lang JE, Yelenosky PF, Lucas WE. 1974; Hematologic assays in pre-eclampsia. American Journal of Obstetrics and Gynecology 118: 362
    CrossrefPubMedGoogle Scholar
  • 11 Mahn I, Müller-Berghaus G. 1975; Studies on catabolism of 125I-labelled fibrinogen in normal rabbits and in rabbits with indwelling intravenous catheters. Methodologic aspects. Haemostasis 4: 40
    PubMedGoogle Scholar
  • 12 McFarlane AS. 1963; In vivo behavior of I131-fibrinogen. Journal of Clinical Investigation 42: 346
    CrossrefPubMedGoogle Scholar
  • 13 Müller-Berghaus G, Moelller RM, Mahn I. 1977. Untersuchungen zur Fibrinogenkinetik bei trächtigen Kaninchen. 21 Tagung der Deutschen Arbeitsgemeinschaft für Blutgerinnungsforschung; Essen:
    Google Scholar
  • 14 Müller-Berghaus G, Moeller RM, Mahn I. 1977. Fibrinogen turnover in pregnant rabbits during the first and the last third of gestation. Submitted for publication
    Google Scholar
  • 15 Nilsson IM, Kullander S. 1967; Coagulation and fibrinolytic studies during pregnancy. Acta Obstetrica et Gynecologica Scandinavica 46: 273
    CrossrefPubMedGoogle Scholar
  • 16 Regoeczi E. 1970. Abnormal fibrinogen metabolism. In: Rothschild MA, Waldmann TA. (eds.) Plasma Protein Metabolism. Regulation of Synthesis, Distribution and Degradation. Academic Press; New York: 459
    CrossrefGoogle Scholar
  • 17 van Royen EA, Ten Cate JW. 1976; Generation of a thrombin-like activity in late pregnancy. Thrombosis Research 8: 487
    CrossrefPubMedGoogle Scholar
  • 18 Sachs L. Angewandte Statistik. 4th edn Springer-Verlag, Berlin, Heidelberg; New York:
    Google Scholar
  • 19 Straub PW. 1976. Zirkulierendes Fibrin und Hyperkoagulabilität. In: Lüscher EF. (ed.) Die Rolle der Blutplattchen bei der Thrombose. Das Problem der Hyperkoagulabilität. Schattauer Verlag; Stuttgart – New York: 95
    Google Scholar
  • 20 Swank RT, Munkres KD. 1971; Molecular weight analysis of oligopeptides by electrophoresis in polyacrylamide gel with sodium dodecyl sulfate. Analytical Biochemistry 39: 462
    CrossrefPubMedGoogle Scholar