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Thromb Haemost 1979; 41(02): 309-313
DOI: 10.1055/s-0038-1646650
Original Articles
Schattauer GmbH Stuttgart

Kinetic Aspects of the Interaction of Blood Clotting Enzymes

VIII. The Relation between Clotting Time and Clotting Velocity
H C Hemker
Department of Biochemistry, State University Limburg, Maastricht, The Netherlands
,
J Kop
Department of Biochemistry, State University Limburg, Maastricht, The Netherlands
,
G M Willems
Department of Biochemistry, State University Limburg, Maastricht, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 12 December 1977

Accepted 15 March 1978

Publication Date:
09 July 2018 (online)

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Summary

It is shown that in a system where thrombin acts on fibrinogen, the clotting time can be used to assess coagulation velocity because clotting time and clotting velocity are inversely proportional.

 

  • References

  • 1 Hemker HC, Hemker PW. 1969; The kinetics of enzyme cascades. Proceedings of the Royal Society B 173: 411
    CrossrefPubMedGoogle Scholar
  • 2 Hemker HC, Siepel T, Altman R, Loeliger EA. 1967; Kinetic aspects of the interaction of blood clotting enzymes. II. The relation between clotting time and plasma concentration in prothrombin-time estimations. Thrombosis et Diathesis Haemorrhagica 17: 350
    PubMedGoogle Scholar
  • 3 Hemker HC, Vermeer C, Govers-Riemslag J. 1977; Kinetic aspects of the interaction of blood clotting enzymes. VII. The relation between clotting time and prothrombin concentration Thrombosis and Haemostasis 37: 81
    Article in Thieme ConnectPubMedGoogle Scholar