Summary
Binding of fibrinogen to platelets washed from blood of migraine patients (n = 30)
and control donors (n = 24) was compared. In addition, contents of platelet glycoprotein
IIb and platelet fibrinogen were determined in both groups by radioimmunoassay. The
receptor capacity for fibrinogen in platelets activated by ADP was significantly higher
(p <0.01) in migraine patients (52,505 α 4,925) than in controls (33,881 λ 3,965).
The mean contents of GPIIb (3.51 α 0.34 μg/108 platelets) and fibrinogen (37 .26 α 4.05 μg/108 platelets) in migraine platelets were also markedly increased (p <0.01 and p <0.001,
respectively) when compared to controls (2.21 α 0.18 μg of GPIIb ano 18.75 λ 2.29
μE of fibrinogen per 108 platelets, respectively). There was a high correlation between the number of fibrinogen
receptors exposed by ADP and the total amount of platelet GPIIb both in migraineurs
(R = 0.69, p <0.01) and controls (R = 0.62, p <0.01,), as well as plasma cholesterol
in the case of migraine patients (R = 0.82, p <0.001)
Keywords
Fibrinogen receptors - Glycoprotein IIb/IIIa complex - Cholesterol - Migraine
