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Thromb Haemost 1989; 61(02): 275-278
DOI: 10.1055/s-0038-1646575
Original Article
Schattauer GmbH Stuttgart

Fibrinolytic Profiles in Local Low-Dose Thrombolysis with Streptokinase and Recombinant Tissue Plasminogen Activator

D C Berridge
1   The Department of Vascular Surgery, University Hospital, Nottingham, UK
,
J J Earnshawl
1   The Department of Vascular Surgery, University Hospital, Nottingham, UK
,
J C Westby
2   The Department of Haematology, University Hospital, Nottingham, UK
,
G S Makin
1   The Department of Vascular Surgery, University Hospital, Nottingham, UK
,
B R Hopkinson
1   The Department of Vascular Surgery, University Hospital, Nottingham, UK
› Author Affiliations
Further Information

Publication History

Received 30 August 1988

Accepted after revision 16 November 1988

Publication Date:
30 June 2018 (online)

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Summary

Fibrinolytic parameters have been monitored in 44 patients undergoing local low-dose intra-arterial thrombolysis for acute peripheral arterial ischaemia. Streptokinase (Sk), at a dose of 5,000 units/hr with 250 units/hr heparin, was used in 23 patients and recombinant tissue plasminogen activator (r-tPA) at a dose of 0.5 mg/hr was used in 21 patients. Successful lysis was seen in 18 (86%) patients following r-tPA and in 15 (65%) patients following streptokinase. There were 4 minor haematomas in each group usually at the catheter entry site. Both agents produced a systemic effect, which was still seen 12 hours post-infusion. However, that produced by r-tPA was delayed and significantly reduced compared to that produced by Sk.

These results confirm the relative fibrin specificity of r-tPA. When used as a continuous low-dose intra-arterial infusion, r-tPA offers a significantly lower, potentially safer, systemic effect than conventional therapy with streptokinase.

Keywords

Acute peripheral ischaemia - Systemic fibrinolysis - Thrombolys - Recombinant tissue plasminogen activator - Streptokinase
 

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