Summary
When compared to normal weight normolipidemic control subjects, dilute blood clot
lysis time was found to be obviously (p <0.001) prolonged in hypertriglyceridemic
patients without proteinuria and slightly (p <0.05) accelerated in hyperlipidemic
nephrotic patients in spite of their very high levels of plasma fibrinogen. As a result
the ratio plasma fibrinogen (mg/dl) per clot lysis time (minutes) was 1.241 ± 0.08
(X ± SEM) in control subjects, 0.574 ± 0.07 in hypertriglyceridemic patients and 2.69
± 0.172 in nephrotic patients. This finding suggesting that a larger amount of fibrin
is rather readily dispersed from dilute blood clots of nephrotic patients was associated
with higher levels of plasma t-PA: Ag (9.45 ng/ml ± 1.18 in nephrotic patients versus
5.8 ng/ml ± 1.23 in controls before venous occlusion and respectively 33.1 ng/ml ±
3.83 versus 20.3 ± 3.40 in controls after venous occlusion). Plasminogen activator
activity of the euglobulins as assessed by the bovine fibrin-agarose plate was significantly
higher in nephrotic patients only after venous occlusion. Plasma samples of nephrotic
patients exerted a more potent inhibition of fibrinolysis in a urokinase activated
system. This effect was, however, mainly due to the high levels of α2 macroglobulin in nephrotic plasma which apparently have little influence on dilute
blood clot lysis time.
Keywords
Tissue-type plasminogen activator - Dilute blood clot lysis time - Nephrotic syndrome
