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Thromb Haemost 1992; 68(05): 511-515
DOI: 10.1055/s-0038-1646309
Original Article
Schattauer GmbH Stuttgart

A Novel Rat Model of Thrombogenicity: Its Use in Evaluation of Prothrombin Complex Concentrates and High Purity Factor IX Concentrates

L F McLaughlin
The National Science Laboratory, Scottish National Blood Transfusion Service, Edinburgh, UK
,
O Drummond
The National Science Laboratory, Scottish National Blood Transfusion Service, Edinburgh, UK
,
I R MacGregor
The National Science Laboratory, Scottish National Blood Transfusion Service, Edinburgh, UK
› Author Affiliations
Further Information

Publication History

Received 14 March 1992

Accepted after revision 22 June 1992

Publication Date:
04 July 2018 (online)

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Summary

A non-stasis rodent model of thrombogenicity has been used for dose-ranging studies with a conventional prothrombin complex concentrate (PCC) and to evaluate high purity factor IX concentrates from different manufacturers. Fibrin monomer (soluble fibrin) and fibrinopeptide A (FPA) were monitored before and after infusion of test solution. FPA was found to be the more sensitive and reproducible indicator of thrombogenicity and exhibited a dose-related elevation after infusion of the PCC at doses of between 100–300 IU/kg. In contrast the amounts of FPA generated after 300 IU/kg of the high purity factor IX products were similar to control infusions of albumin.

 

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