Factor XII, Plasma Prekallikrein, α2-Macroglobulin and C1-Inhibitor Levels in Renal Allograft Recipients During Immunosuppression with Cyclosporin A – Sequential Measurements over Four Months in 17 Patients

A Lohri; B Huser; B Lämmle; M Oberholzer; G Thiel; F Duckert

doi:10.1055/s-0038-1646043

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1987; 58(04): 993-997
DOI: 10.1055/s-0038-1646043

Original Article

Schattauer GmbH Stuttgart

Factor XII, Plasma Prekallikrein, α₂-Macroglobulin and C1-Inhibitor Levels in Renal Allograft Recipients During Immunosuppression with Cyclosporin A – Sequential Measurements over Four Months in 17 Patients

Authors

A Lohri

The Coagulation and Fibrinolysis Laboratory, Kantonsspital, Basel, Switzerland
B Huser

^*The Department of Nephrology, Kantonsspital, Basel, Switzerland
B Lämmle

The Coagulation and Fibrinolysis Laboratory, Kantonsspital, Basel, Switzerland
M Oberholzer

^**The Department of Pathology, Kantonsspital, Basel, Switzerland
G Thiel

^*The Department of Nephrology, Kantonsspital, Basel, Switzerland
F Duckert

The Coagulation and Fibrinolysis Laboratory, Kantonsspital, Basel, Switzerland

Abstract

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Summary

Factor XII clotting activity (F XII), plasma prekallikrein amidolytic activity (PK), α₂-Macroglobulin (α₂-M) and C1-Inhibitor (C1-Inh) antigens have been measured in 17 patients immediately before and sequentially for up to four months after kidney transplantation. Before transplantation mean F XII and PK levels were normal (99 ± 27% and 102 ± 21%, respectively, mean ± S. D.) and α₂-M and C1-Inh levels were slightly elevated (115 ± 55% and 129 ± 32%, respectively, mean ± S. D.). In the first two weeks after transplantation a significant decrease of F XII to 65 ± 27%, of PK to 67 ± 20% and of α₂-M to 88 ± 42%, and a rise of C1-Inh to 201 ± 44% (mean ± S. D.) were observed (2 p <0.005). F XII levels four month after operation remained significantly (2 p <0.05) lower than preoperatively. PK and α₂-M values, however, were significantly higher (2 p <0.05) at four months as compared to the pretransplant period. Mean F XII levels in the 17 patients at various time points after transplantation correlated positively with PK, α₂-M and serum albumin and negatively with CyA level and dose and serum bilirubin. PK and α₂-M correlated positively with each other and albumin and negatively with creatinine, bilirubin and CyA (2 p <0.01). Whether CyA has a direct influence on production or consumption of F XII, PK, α₂-M and C1-Inh, or whether the changes merely reflect altered protein metabolism awaits further study.

Keywords

Factor XII - Plasma prekallikrein - α₂-Macroglobulin - C1-Inhibitor - Kidney transplantation - Cyclosporin A

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References

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