CC-BY-NC-ND 4.0 · AJP Rep 2018; 08(02): e85-e88
DOI: 10.1055/s-0038-1645879
Case Report
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Neonatal Thyrotoxicosis with Tricuspid Valve Regurgitation and Hydrops in a Preterm Infant Born to a Mother with Graves' Disease

Stefani Doucette
Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Canada
,
Anne Tierney
Section of Neonatology, Department of Pediatrics, University of Calgary, Cumming School of Medicine, Alberta, Canada
,
Anne Roggensack
Department of Obstetrics and Gynecology, University of Calgary, Cumming School of Medicine, Alberta, Canada
,
Kamran Yusuf
Section of Neonatology, Department of Pediatrics, University of Calgary, Cumming School of Medicine, Alberta, Canada
› Author Affiliations
Further Information

Publication History

18 October 2017

15 January 2018

Publication Date:
04 May 2018 (online)

Abstract

Neonatal hyperthyroidism is rare disorder due to the passage of thyroid receptor antibodies (TRBs) from the mother to the fetus. Neonatal thyrotoxicosis can present in several ways and if unrecognized, can be fatal. We present a preterm neonate who developed fetal hydrops and tricuspid regurgitation in utero. The mother had a history of treated Grave's disease. The infant responded to maternal treatment antenatally and postnatal anti-thyroid treatment, with resolution of both the tricuspid regurgitation and hydrops. To our knowledge, this is the first case report of tricuspid regurgitation associated with fetal and neonatal thyrotoxicosis. Our case also highlights the importance of obtaining a detailed and accurate history in a mother with previous Grave's disease, even if treated.